Evidence map›Paper›PMID 41596376›Full record

ArticleInternational journal of molecular sciences2026

The H159Y Variant of the BAFF-R Gene (

Itzel María Borunda-Calderón, Jazz Alan Corona-Angeles, Noemí Espinoza-García, Miguel Marín-Rosales, Diana Celeste Salazar-Camarena, Edith Oregon-Romero, Ramsés Alejandro Morales-Zambrano, Claudia Azucena Palafox-Sánchez

Abstract read
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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Itzel María Borunda-CalderónDoctorado en Ciencias Biomédicas, Departamento de Fisiología, Centro Universitario en Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.
Jazz Alan Corona-AngelesDoctorado en Ciencias Biomédicas, Departamento de Fisiología, Centro Universitario en Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.
Noemí Espinoza-GarcíaInstituto de Biología Molecular en Medicina y Terapia Génica, Departamento de Biología Molecular, Centro Universitario en Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0001-9001-6003
Miguel Marín-RosalesDepartamento de Reumatología, Hospital General de Occidente, Zapopan 45170, Jalisco, Mexico.ORCID 0000-0003-1658-8630
Diana Celeste Salazar-CamarenaInstituto de Biología Molecular en Medicina y Terapia Génica, Departamento de Biología Molecular, Centro Universitario en Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0001-7814-0191
Edith Oregon-RomeroInstituto de Investigación en Ciencias Biomédicas, Departamento de Clínicas Médicas, Centro Universitario en Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0001-6010-0837
Ramsés Alejandro Morales-ZambranoInstituto de Investigación en Ciencias Biomédicas, Departamento de Clínicas Médicas, Centro Universitario en Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.
Claudia Azucena Palafox-SánchezInstituto de Investigación en Ciencias Biomédicas, Departamento de Clínicas Médicas, Centro Universitario en Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0003-0836-4186

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic Lupus Erythematosus (SLE) and primary Sjögren's Disease (SjD) are autoimmune diseases characterized by the presence of autoantibodies that lead to damage in healthy tissues. The production of autoantibodies requires the activation and differentiation of B-lymphocytes into plasma cells. To achieve this effect, BAFF (B-lymphocyte activating factor), APRIL (A proliferation-inducing ligand), and their receptors are key factors. BAFF is a cytokine recognized by BAFF-R (BAFF receptor), which is increased and related to disease activity in both SLE and SjD patients. The H159Y mutation (rs61756766) in the gene encoding the BAFF-R,

Indexed as

B-Cell Activation Factor ReceptorGenetic Predisposition to DiseaseLupus Erythematosus, SystemicPolymorphism, Single NucleotideSjogren's SyndromeAdultB-Cell Activating FactorCase-Control StudiesFemaleGene FrequencyGenotypeHumansMaleMexicoMiddle AgedB-Cell Activating FactorB-Cell Activation Factor ReceptorTNFRSF13C protein, humanBAFF-Rsingle-nucleotide polymorphismSjögren’s DiseaseSystemic Lupus Erythematosus

Identifiers

PMID41596376
PMCPMC12841347

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.