Evidence map›Paper›PMID 41596232›Full record

ArticleInternational journal of molecular sciences2026

Hyaluronan of Different Molecular Weights Exerts Distinct Therapeutic Effects on Bleomycin-Induced Acute Respiratory Distress Syndrome.

Shu-Ting Peng, Chia-Yu Lai, Tsui-Ling Ko, Chun-Hsiang Hsu, I-Yuan Chen, You-Cheng Jiang, Kuo-An Chu, Yu-Show Fu

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shu-Ting PengDepartment of Anatomy and Cell Biology, School of Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.ORCID 0009-0006-6186-8972
Chia-Yu LaiInstitute of Anatomy and Cell Biology, School of Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.
Tsui-Ling KoSchool of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Chun-Hsiang HsuDivision of Chest Medicine, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan.
I-Yuan ChenDivision of Chest Medicine, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan.
You-Cheng JiangDivision of Chest Medicine, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan.
Kuo-An ChuSchool of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Yu-Show FuDepartment of Anatomy and Cell Biology, School of Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.ORCID 0000-0002-4754-6006

Funding

Kaohsiung Veterans General Hospital. KSVGH111-13, KSVGH114-015, and KSVGH114-081Yin Shu-Tien Foundation Development and Construction Plan of the College of Medicine, National Yang Ming Chiao Tung University 113Q159604 and 114Q153602
6 · The paper itself

Abstract

Acute respiratory distress syndrome (ARDS) is a fatal inflammatory lung disorder with few effective treatments. Hyaluronan (HA), a major extracellular matrix component, exhibits diverse biological activities depending on its molecular weight. This study aimed to evaluate the therapeutic potential of HA of various molecular weights in a rat model of ARDS. ARDS was induced in rats via the intratracheal instillation of 5 mg of bleomycin. Seven days later, when ARDS symptoms developed, low (LHA), medium (MHA), high (HHA), and mixed (MIX HA) hyaluronan were intratracheally administered seven times from Days 7 to 28. On Day 7, arterial oxygen saturation (SpO

Indexed as

BleomycinHyaluronic AcidRespiratory Distress SyndromeAnimalsCollagenDisease Models, AnimalLungMacrophagesMaleMatrix Metalloproteinase 2Matrix Metalloproteinase 9Molecular WeightRatsToll-Like Receptor 4Vascular Endothelial Growth Factor ABleomycinCollagenHyaluronic AcidMatrix Metalloproteinase 2Matrix Metalloproteinase 9Mmp2 protein, ratTlr4 protein, ratToll-Like Receptor 4Vascular Endothelial Growth Factor Aacute lung injuryacute respiratory distress syndromehyaluronanimmune stormlung functionmacrophage

Identifiers

PMID41596232
PMCPMC12840770

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.