Evidence map›Paper›PMID 41596226›Full record

ReviewInternational journal of molecular sciences2026

The Zinc Finger Ran-Binding Protein 3 (ZRANB3): An Advanced Perspective.

Paride Pelucchi, Ettore Mosca, Nika Tomsič, Yossma Waheed, Wendalina Tigani, Alice Chiodi, Aditya Mojumdar, Marco Gerdol, Matteo De March

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Paride PelucchiIstituto di Tecnologie Biomediche (ITB), Consiglio Nazionale delle Ricerche (CNR), Via Fratelli Cervi 93, 20054 Milano, Italy.ORCID 0000-0001-5415-1515
Ettore MoscaIstituto di Tecnologie Biomediche (ITB), Consiglio Nazionale delle Ricerche (CNR), Via Fratelli Cervi 93, 20054 Milano, Italy.ORCID 0000-0002-3102-5150
Nika TomsičLaboratory for Environmental and Life Sciences, University of Nova Gorica, Vipavska 13, SI-5000 Nova Gorica, Slovenia.
Yossma WaheedLaboratory for Environmental and Life Sciences, University of Nova Gorica, Vipavska 13, SI-5000 Nova Gorica, Slovenia.
Wendalina TiganiDepartment of Life Science, University of Trieste, Via Licio Giorgieri 5, 34100 Trieste, Italy.ORCID 0000-0002-2867-6630
Alice ChiodiIstituto di Tecnologie Biomediche (ITB), Consiglio Nazionale delle Ricerche (CNR), Via Fratelli Cervi 93, 20054 Milano, Italy.ORCID 0000-0001-6646-4471
Aditya MojumdarDepartment of Biochemistry and Microbiology, University of Victoria, Victoria, BC V8W 2Y2, Canada.ORCID 0000-0003-0254-6958
Marco GerdolDepartment of Life Science, University of Trieste, Via Licio Giorgieri 5, 34100 Trieste, Italy.ORCID 0000-0001-6411-0813
Matteo De MarchLaboratory for Environmental and Life Sciences, University of Nova Gorica, Vipavska 13, SI-5000 Nova Gorica, Slovenia.ORCID 0000-0002-3447-957X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human zinc finger Ran-binding protein 3 (ZRANB3) is crucial for DNA damage tolerance (DDT), as it prevents excessive damage, restores fork progression, and ultimately maintains genome stability. This unique and ancient architecture mainly exerts its function during replication fork reversal (RFR) and within the p53/Polι axis; thus, ZRANB3 is considered a tumour suppressor. However, possible additional roles in DNA synthesis and cell metabolism have been proposed. In tumour cells,

Indexed as

NeoplasmsAnimalsDNA DamageDNA Damage ToleranceDNA ReplicationGene Expression Regulation, NeoplasticHumansMutationTumor Suppressor Protein p53Tumor Suppressor Protein p53ATP-ase translocasecancerDNA repairfork remodelertumour suppressor

Identifiers

PMID41596226
PMCPMC12841045

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.