Drosophila Keap1 Proteins Assemble Nuclear Condensates in Response to Oxidative Stress.

Guangye Ji, Bethany Cross, Thomas Killmer, Bee Enders, Emma Neidviecky, Hayden Huber, Grace Lynch, Huai Deng

Abstract read

In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Guangye JiDepartment of Biology, University of Minnesota Duluth, Duluth, MN 55812, USA.

Bethany CrossDepartment of Biology, University of Minnesota Duluth, Duluth, MN 55812, USA.

Thomas KillmerDepartment of Biology, University of Minnesota Duluth, Duluth, MN 55812, USA.

Bee EndersDepartment of Biology, University of Minnesota Duluth, Duluth, MN 55812, USA.ORCID 0009-0009-7724-4920

Emma NeidvieckyDepartment of Biology, University of Minnesota Duluth, Duluth, MN 55812, USA.

Hayden HuberDepartment of Biology, University of Minnesota Duluth, Duluth, MN 55812, USA.

Grace LynchDepartment of Biology, University of Minnesota Duluth, Duluth, MN 55812, USA.ORCID 0009-0005-5915-4244

Huai DengDepartment of Biology, University of Minnesota Duluth, Duluth, MN 55812, USA.ORCID 0000-0001-5867-3572

Funding

NIH HHS 2R15GM128143-02

6 · The paper itself

Abstract

The Keap1-Nrf2 signaling pathway is a central regulator of transcriptional responses to oxidative stress and is strongly linked to diverse pathologies, particularly cancer. In the cytoplasm, Keap1 (Kelch-like ECH-associated protein 1) promotes proteasomal degradation of Nrf2 (NF-E2-related factor 2). Oxidative stimuli disrupt the Keap1-Nrf2 interaction, facilitating Nrf2 nuclear accumulation and activation of antioxidant and detoxifying genes. Recent evidence suggests that Keap1 family proteins also enter the nucleus, bind chromatin, and regulate transcription, but the underlying mechanisms remain less understood. Here, we show that the

Indexed as

biomolecular condensatesdKeap1Keap1-Nrf2 oxidative response signaling

Identifiers

PMID41596192

DOI10.3390/antiox15010134

PMCPMC12838377

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