ENOX2 (tNOX)-Associated Stemness in Oral Cancer Cells and Its Clinical Correlation in Head and Neck Tumors.

Che-Wei Wang, Atikul Islam, Yu-Tung Shih, Chin-Fang Chang, Mu Kuan Chen, Pin Ju Chueh

Abstract read

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Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 citing paper in PubMed.

p53-Dependent ENOX2 Downregulation Mediates the Apoptotic Responses to Heteroarene-Fused Anthraquinones in Colon Cancer Cells.Biomolecules · 2026
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6 authors.

Che-Wei WangGraduate Institute of Biomedical Sciences, College of Medicine, National Chung Hsing University, Taichung 402202, Taiwan.

Atikul IslamGraduate Institute of Biomedical Sciences, College of Medicine, National Chung Hsing University, Taichung 402202, Taiwan.

Yu-Tung ShihGraduate Institute of Biomedical Sciences, College of Medicine, National Chung Hsing University, Taichung 402202, Taiwan.

Chin-Fang ChangDepartment of Otolaryngology, Head and Neck Surgery, Jen-Ai Hospital, Taichung 412224, Taiwan.ORCID 0000-0002-0579-0836

Mu Kuan ChenDepartment of Otorhinolaryngology-Head and Neck Surgery, Changhua Christian Hospital, Changhua 500209, Taiwan.

Pin Ju ChuehGraduate Institute of Biomedical Sciences, College of Medicine, National Chung Hsing University, Taichung 402202, Taiwan.ORCID 0000-0002-3200-7552

Funding

the National Chung Hsing University and Changhua Christian Hospital, Taiwan NCHU-CCH-11105the National Science and Technology Council, ROC MOST-109-2314-B-816-001-MY2the National Science and Technology Council, ROC MOST 109-2320-B-005-010the National Science and Technology Council, ROC NSC 102-2320-B005-008

6 · The paper itself

Abstract

Cancer remains one of the most common causes of death worldwide and imposes enormous social and economic burdens. Human tumor-associated NADH oxidase (ENOX2, also known as tNOX) is a cancer cell-specialized NADH oxidase that is expressed on the membranes of cancer cells. In this study, we investigated the potential role of ENOX2 in regulating stemness properties in oral cancer through a combination of in vitro, in vivo, and bioinformatics approaches. We found that ENOX2 physically interacted with the stem cell transcription factor, SOX2, in co-immunoprecipitation experiments. The expression and activity of ENOX2 were elevated in

Indexed as

3-D sphere culturecancer stem cells (CSCs)head and neck cancersex-determining region Y box 2 (SOX2)silent information regulator 1 (Sirtuin1SIRT1)stemnesstNOX)tumor-associated NADH oxidase (ENOX2

Identifiers

PMID41596158

DOI10.3390/antiox15010098

PMCPMC12837915

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.