Evidence map›Paper›PMID 41596097›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Inhibition of TRPC3-Nox2 Complex Formation Ameliorates Skeletal Muscle Atrophy.

Yuri Kato, Di Wu, Tomoya Ito, Yara Atef, Koichi Ayukawa, Xinya Mi, Kazuhiro Nishiyama, Akiyuki Nishimura, Motohiro Nishida

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuri KatoGraduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.ORCID 0000-0002-9426-911X
Di WuGraduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Tomoya ItoGraduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.ORCID 0000-0002-1858-6009
Yara AtefGraduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.ORCID 0000-0002-1232-7268
Koichi AyukawaGraduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Xinya MiGraduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Kazuhiro NishiyamaGraduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.ORCID 0000-0002-6263-3562
Akiyuki NishimuraDivision of Cardiocirculatory Signaling, National Institute for Physiological Sciences & Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences, Okazaki 444-8787, Japan.ORCID 0000-0003-2309-3994
Motohiro NishidaGraduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.ORCID 0000-0002-2587-5458

Funding

Grant-in-Aid for Scientific Research on Innovative Areas (A) 21H05269, 21H05258International Leading Research "Global Exploration for Redox Supermolecules Evolving in Life Functions" 23K20040Japan Agency for Medical Research and Development JP24ama121031Japan Science and Technology Agency JPMJCR2024 (20348438)Japan Society for the Promotion of Science 23K06164, 24K02202, 24K02869, 24K21306, 25K03490The Exploratory Research Center on Life and Living Systems 25EXC318
6 · The paper itself

Abstract

Skeletal muscle atrophy underlies sarcopenia, frailty, and muscular dystrophies, but the molecular mechanisms linking oxidative stress to muscle degeneration remain incompletely understood. We previously identified protein complex formation between transient receptor potential canonical 3 (TRPC3) and NADPH oxidase 2 (Nox2) as a key driver of anthracycline-induced myocardial atrophy. Here, we investigated whether this complex also contributes to skeletal muscle wasting. In skeletal muscle from sciatic nerve transection model mice and Duchenne muscular dystrophy (

Indexed as

Nox2protein–protein interactionskeletal muscle atrophyTRPC3

Identifiers

PMID41596097
PMCPMC12838269

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.