Evidence map›Paper›PMID 41596041›Full record

ArticleBioengineering (Basel, Switzerland)2026

bFGF-Loaded PDA Microparticles Enhance Vascularization of Engineered Skin with a Concomitant Increase in Leukocyte Recruitment.

Britani N Blackstone, Zachary W Everett, Syed B Alvi, Autumn C Campbell, Emilio Alvalle, Olivia Borowski, Jennifer M Hahn, Divya Sridharan, Dorothy M Supp, Mahmood Khan and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Britani N BlackstoneDepartment of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-2884-8324
Zachary W EverettDepartment of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USA.ORCID 0009-0008-7733-2907
Syed B AlviDivision of Basic and Translational Research, Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0003-3533-840X
Autumn C CampbellDepartment of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USA.
Emilio AlvalleDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA.
Olivia BorowskiDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA.
Jennifer M HahnShriners Children's Ohio, Dayton, OH 45404, USA.ORCID 0009-0007-9017-4053
Divya SridharanDivision of Basic and Translational Research, Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0003-1931-6470
Dorothy M SuppShriners Children's Ohio, Dayton, OH 45404, USA.ORCID 0000-0002-2429-6630
Mahmood KhanDivision of Basic and Translational Research, Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0003-3430-374X
Heather M PowellDepartment of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-6845-8101

Funding

In Situ Skin Regeneration and Angiogenesis for Full-Thickness BurnsR01AR080946 · NIAMS · OHIO STATE UNIVERSITY · PI Mahmood Khan, Heather M Powell · 2023 to 2026
$2.3M
American Heart Association 25TPA1481526National Heart Lung and Blood Institute HL157453NIAMS NIH HHS 1R01AR080946-01A1NIAMS NIH HHS R01 AR080946Shriners Hospitals for Children 71003-OHI-22United States Department of Defense HT9425-23-1-0592
6 · The paper itself

Abstract

Engineered skin (ES) can serve as an advanced therapy for treatment of large full-thickness wounds, but delayed vascularization can cause ischemia, necrosis, and graft failure. To accelerate ES vascularization, this study assessed incorporation of polydopamine (PDA) microparticles loaded with different concentrations of basic fibroblast growth factor (bFGF) into collagen scaffolds, which were subsequently seeded with human fibroblasts to create dermal templates (DTs), and then keratinocytes to create ES. DTs and ES were evaluated in vitro and following grafting to full-thickness wounds in immunodeficient mice. In vitro, metabolic activity of DTs was enhanced with PDA+bFGF, though this increase was not observed following seeding with keratinocytes to generate ES. After grafting, ES with bFGF-loaded PDA microparticles displayed dose-dependent increases in CD31-positive vessel formation vs. PDA-only controls (

Indexed as

basic fibroblast growth factordermal templatedrug releaseengineered skinpolydopaminevascularization

Identifiers

PMID41596041
PMCPMC12837753

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.