ArticleInternational journal of environmental research and public health2025
Association Between Low-Level Lead Exposure and Serum Gamma-Glutamyl Transferase Concentrations as a Biomarker of Oxidative Stress in U.S. Adolescents Aged 12-19 Years.
Article in International journal of environmental research and public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesThis study aims to investigate the potential relationship between low-level lead exposure and serum gamma-glutamyl transferase (GGT) concentrations, which may serve as a biomarker of oxidative stress in U.S. adolescents.
methodsWe used NHANES data from 1999 to 2000 to 2017-2018. Analyses were limited to adolescents aged 12-19 years with blood lead levels (BLLs) below 5 µg/dL (
resultsAdolescents with BLLs ≥ 0.70 µg/dL showed significantly higher serum GGT concentrations compared to those with BLLs < 0.70 µg/dL (geometric means: 13.94 vs. 12.80 U/L;
conclusionsIn the present study, we observed that higher BLLs were associated with higher serum GGT concentrations in U.S. adolescents aged 12-19 years. Further research is needed to substantiate the positive relationship between BLLs and serum GGT and explore the mechanisms underlying their interaction with oxidative stress in adolescents.
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