Evidence map›Paper›PMID 41595749›Full record

ReviewBiomedicines2026

Targeting Cancer Stem Cells with Phytochemicals: Molecular Mechanisms and Therapeutic Potential.

Ashok Kumar Sah, Joy Das, Abdulkhakov Ikhtiyor Umarovich, Shagun Agarwal, Pranav Kumar Prabhakar, Ankur Vashishtha, Rabab H Elshaikh, Ranjay Kumar Choudhary, Ayman Hussein Alfeel

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomedicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ashok Kumar SahDepartment of Medical Laboratory Sciences, College of Applied and Health Sciences, A' Sharqiyah University, Ibra 400, Oman.ORCID 0000-0002-7762-4351
Joy DasSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, Punjab, India.ORCID 0009-0009-0251-1633
Abdulkhakov Ikhtiyor UmarovichDepartment of Faculty and Hospital Therapy, Bukhara State Medical Institute, Bukhara 200100, Uzbekistan.
Shagun AgarwalSchool of Allied Health Sciences, Galgotias University, Greater Noida 203201, Uttar Pradesh, India.ORCID 0000-0003-4265-2958
Pranav Kumar PrabhakarDepartment of Biotechnology, School of Engineering and Technology, Nagaland University, Meriema, Kohima 797004, Nagaland, India.ORCID 0000-0001-8130-1822
Ankur VashishthaDepartment of Medical Laboratory Technology, School of Allied Health Sciences, Sharda University, Greater Noida 201310, Uttar Pradesh, India.ORCID 0000-0003-0679-5126
Rabab H ElshaikhDepartment of Medical Laboratory Sciences, College of Applied and Health Sciences, A' Sharqiyah University, Ibra 400, Oman.ORCID 0000-0003-0973-8661
Ranjay Kumar ChoudharyDepartment of Medical Laboratory Sciences, College of Applied and Health Sciences, A' Sharqiyah University, Ibra 400, Oman.
Ayman Hussein AlfeelMedical Laboratory Sciences Department, College of Health and Applied Sciences, Gulf Medical University, Ajman 4184, United Arab Emirates.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer stem cells (CSCs) represent a small but highly resilient tumor subpopulation responsible for sustained growth, metastasis, therapeutic resistance, and recurrence. Their survival is supported by aberrant activation of developmental and inflammatory pathways, including Wnt/β-catenin, Notch, Hedgehog, PI3K/Akt/mTOR, STAT3, and NF-κB, as well as epithelial-mesenchymal transition (EMT) programs and niche-driven cues. Increasing evidence shows that phytochemicals, naturally occurring bioactive compounds from medicinal plants, can disrupt these networks through multi-targeted mechanisms. This review synthesizes current findings on prominent phytochemicals such as curcumin, sulforaphane, resveratrol, EGCG, genistein, quercetin, parthenolide, berberine, and withaferin A. Collectively, these compounds suppress CSC self-renewal, reduce sphere-forming capacity, diminish ALDH

Indexed as

anticancer activitycancer stem cellschemoresistancemedicinal plantsphytochemicalsstemness pathways

Identifiers

PMID41595749
PMCPMC12838567

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.