Evidence map›Paper›PMID 41595525›Full record

ArticleGenes2026

Optical Genome Mapping Enhances Structural Variant Detection and Refines Risk Stratification in Chronic Lymphocytic Leukemia.

Soma Roy Chakraborty, Michelle A Bickford, Narcisa A Smuliac, Kyle A Tonseth, Jing Bao, Farzana Murad, Irma G Domínguez Vigil, Heather B Steinmetz, Lauren M Wainman, Parth Shah and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Soma Roy ChakrabortyDivision of Hematopathology, Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA.
Michelle A BickfordLaboratory for Clinical Genomics and Advanced Technology (CGAT), Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA.
Narcisa A SmuliacLaboratory for Clinical Genomics and Advanced Technology (CGAT), Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA.
Kyle A TonsethLaboratory for Clinical Genomics and Advanced Technology (CGAT), Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA.
Jing BaoLaboratory for Clinical Genomics and Advanced Technology (CGAT), Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA.
Farzana MuradLaboratory for Clinical Genomics and Advanced Technology (CGAT), Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA.
Irma G Domínguez VigilLaboratory for Clinical Genomics and Advanced Technology (CGAT), Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA.ORCID 0000-0003-4687-6318
Heather B SteinmetzLaboratory for Clinical Genomics and Advanced Technology (CGAT), Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA.
Lauren M WainmanLaboratory for Clinical Genomics and Advanced Technology (CGAT), Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA.ORCID 0009-0001-2295-111X
Parth ShahGeisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA.
Elizabeth M BengtsonGeisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA.
Swaroopa PonnamReddyGeisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA.
Gabriella A HarmonGeisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA.
Liam L DonnellyDivision of Hematopathology, Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA.
Laura J TafeGeisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA.
Jeremiah X KarrsDivision of Hematopathology, Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA.
Prabhjot KaurDivision of Hematopathology, Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA.
Wahab A KhanGeisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA.ORCID 0000-0002-7785-2899

Funding

Centers of Biomedical Research Excellence Pilot Grant DGR16033
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Chromosome MappingGenomic Structural VariationLeukemia, Lymphocytic, Chronic, B-CellAgedAged, 80 and overBaculoviral IAP Repeat-Containing 3 ProteinChromosome DeletionFemaleHigh-Throughput Nucleotide SequencingHumansImmunoglobulin Heavy ChainsIn Situ Hybridization, FluorescenceMaleMiddle AgedMutationRetrospective StudiesBaculoviral IAP Repeat-Containing 3 ProteinBIRC3 protein, humanImmunoglobulin Heavy Chainschronic lymphocytic leukemiaFISHIGHV mutation statusnext-generation sequencingoptical genome mappingstructural variantstime-to-first treatment

Identifiers

PMID41595525
PMCPMC12840957

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.