Evidence map›Paper›PMID 41595464›Full record

ArticleGenes2025

REV1 Loss Triggers a G2/M Cell-Cycle Arrest Through Dysregulation of Mitotic Regulators.

Brailey Buntin, Madison Guyette, Vihit Gupta, Kanayo Ikeh, Sombodhi Bhattacharya, Erica N Lamkin, Allison Lafuze, Roxana Del Rio-Guerra, Jiyong Hong, Pei Zhou and 1 more

Abstract read
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Brailey BuntinDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.ORCID 0009-0004-9513-1157
Madison GuyetteDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.ORCID 0009-0006-6084-5787
Vihit GuptaDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.ORCID 0009-0008-9007-165X
Kanayo IkehDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.ORCID 0000-0003-4610-3489
Sombodhi BhattacharyaDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.ORCID 0009-0004-9411-9973
Erica N LamkinSylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.ORCID 0000-0002-2404-5129
Allison LafuzeDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.ORCID 0009-0002-8952-5614
Roxana Del Rio-GuerraLarner College of Medicine, University of Vermont, Burlington, VT 05405, USA.ORCID 0000-0001-6871-3259
Jiyong HongDepartment of Chemistry, Duke University, Durham, NC 27708, USA.ORCID 0000-0002-5253-0949
Pei ZhouDepartment of Biochemistry, Duke University, Durham, NC 27710, USA.ORCID 0000-0002-7823-3416
Nimrat ChatterjeeDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.ORCID 0000-0001-6556-9423

Funding

Inhibiting Rev1-mediated translesion DNA synthesis for cancer therapyR01CA279034 · NCI · DUKE UNIVERSITY · PI Jiyong Hong, Pei Zhou · 2024 to 2026
$1.6M
Mechanistic insights into translesion synthesis-dependent genome instabilityR35GM150992 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Nimrat Chatterjee · 2023 to 2026
$1.5M
NCI NIH HHS CA279034NCI NIH HHS R01 CA279034NIGMS NIH HHS R35 GM150992NIGMS NIH HHS R35GM150992
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

G2 Phase Cell Cycle CheckpointsMitosisNuclear ProteinsNucleotidyltransferasesCyclin B1DNA DamageDNA ReplicationHumansTranslesion DNA SynthesisTubulinY-Family DNA PolymerasesCCNB1 protein, humanCyclin B1Nuclear ProteinsNucleotidyltransferasesREV1 protein, humanTubulinY-Family DNA PolymerasesCyclin B1G2/M arrestJH-RE-06REV1translesion synthesis (TLS)tubulins

Identifiers

PMID41595464
PMCPMC12841074

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.