ArticleGenes2025
Multiomics Profiling Unveils Key Genes and Metabolites Involved in the Salt Tolerance of
Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
6 authors.
Funding
Abstract
backgroundSalt stress is a primary abiotic constraint on cotton growth, significantly impairing yield and fiber quality.
methodsTo elucidate the regulatory mechanisms underlying salt stress responses in
resultsWe identified 33,975 differentially expressed genes (DEGs), with significant enrichment in pathways related to plant hormone signal transduction, amino acid metabolism, and starch and sucrose metabolism. K-means clustering grouped the DEGs into six expression modules corresponding to distinct response stages. Additionally, UPLC-MS analysis identified 6292 metabolites-spanning lipids, carbohydrates, and amino acids-and revealed substantial metabolic reprogramming with increasing stress duration. An integrated multiomics analysis highlighted the ABC transporter and starch and sucrose metabolism pathways as key regulatory modules for salt tolerance and identified critical genes within them.
conclusionsCollectively, these findings provide a comprehensive view of the transcriptional and metabolic dynamics of
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