Evidence map›Paper›PMID 41594916›Full record

ArticleBiology2026

Mitochondrial Adaptations Underlying Tetraploidization in Human Cancer, Fungal, and Yeast Models.

Mohamed Jemaà, Ameni Bedoui, Nihel Ammous, Ali Gargouri, Mohamed Guerfali

Abstract read
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mohamed JemaàHuman Genetics Laboratory, Faculty of Medicine of Tunis, Tunis El Manar University, 5, Rue Hassouna Ben Ayed-1007 Bab Saadoun Tunis, Tunis 2092, Tunisia.ORCID 0000-0003-4905-1020
Ameni BedouiLaboratory of Molecular Biotechnology of Eukaryotes, LMBE, Centre of Biotechnology of Sfax, P.O. Box 1177, Sfax 3038, Tunisia.
Nihel AmmousLaboratory of Molecular Biotechnology of Eukaryotes, LMBE, Centre of Biotechnology of Sfax, P.O. Box 1177, Sfax 3038, Tunisia.ORCID 0000-0002-5744-0328
Ali GargouriLaboratory of Molecular Biotechnology of Eukaryotes, LMBE, Centre of Biotechnology of Sfax, P.O. Box 1177, Sfax 3038, Tunisia.ORCID 0000-0001-5009-9000
Mohamed GuerfaliLaboratory of Molecular Biotechnology of Eukaryotes, LMBE, Centre of Biotechnology of Sfax, P.O. Box 1177, Sfax 3038, Tunisia.ORCID 0000-0002-0594-6343

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Whole-genome duplication, or tetraploidization, occurs in cells, tissues, or entire organisms. In human cancers, tetraploidization promotes aneuploidy and genomic instability, accelerating tumor progression, metastasis, and drug resistance. These adaptations demand metabolic rewiring, including mitochondrial plasticity. Here, we investigate the relationship between mitochondrial quantity/activity, including the mitochondrial transmembrane potential, the intracellular calcium, and the oxidative stress in diploid versus tetraploid cancer cells (colon, sarcoma, liver) and fungal and yeast models (

Indexed as

flow cytometrymitochondriamtDNApolyploidysize

Identifiers

PMID41594916
PMCPMC12837461

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.