Evidence map›Paper›PMID 41594843›Full record

ArticleBiology2026

Energy-Dense High-Fat/High-Sucrose Diet to Induce Type 2 Diabetes Mellitus in BALB/c Mice Without Genetic Modifications and Chemical Agents.

Alma Nelly Diaz-Herreros, Amaranta Sarai Valdez-Guerrero, Juan Carlos Cancino-Díaz, Luvia Enid Sánchez-Torres, Fernando Gómez-Chávez, Mónica Gricelda Arellano-Mendoza, Feliciano Tamay-Cach, Mario Eugenio Cancino-Diaz

Abstract read
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alma Nelly Diaz-HerrerosLaboratorio de Inmunología Aplicada, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala s/n, Col. Santo Tomas, Delg. Miguel Hidalgo, Mexico City 11340, Mexico.ORCID 0000-0001-6058-6611
Amaranta Sarai Valdez-GuerreroLaboratorio de Bioquímica Aplicada, Escuela Superior de Medicina del Instituto Politécnico Nacional, Mexico City 11340, Mexico.ORCID 0000-0001-7577-6290
Juan Carlos Cancino-DíazLaboratorio de Inmunología y Microbiología, Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala s/n, Col. Santo Tomas, Delg. Miguel Hidalgo, Mexico City 11340, Mexico.ORCID 0000-0002-3708-7010
Luvia Enid Sánchez-TorresLaboratorio de Inmunología de los Microorganismos, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala s/n, Col. Santo Tomas, Delg. Miguel Hidalgo, Mexico City 11340, Mexico.ORCID 0000-0002-7128-849X
Fernando Gómez-ChávezLaboratorio de Enfermedades Osteoarticulares e Inmunológicas, Sección de Estudios de Posgrado e Investigación, Escuela Nacional de Medicina y Homeopatia del Instituto Politécnico Nacional, Av. Guillermo Massieu Helguera 239, Mexico City 07320, Mexico.ORCID 0000-0002-5050-2143
Mónica Gricelda Arellano-MendozaLaboratorio de Enfermedades Crónico Degenerativas, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina del Instituto Politécnico Nacional, Mexico City 11340, Mexico.
Feliciano Tamay-CachLaboratorio de Bioquímica Aplicada, Escuela Superior de Medicina del Instituto Politécnico Nacional, Mexico City 11340, Mexico.ORCID 0000-0002-3897-6477
Mario Eugenio Cancino-DiazLaboratorio de Inmunología Aplicada, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala s/n, Col. Santo Tomas, Delg. Miguel Hidalgo, Mexico City 11340, Mexico.ORCID 0000-0003-0271-7892

Funding

Instituto Politécnico Nacional SIP-20253840Secretaría de Ciencia Tecnología e Innovación CF-2023-I-1131
6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) is a highly prevalent disease characterized by chronic hyperglycemia, commonly associated with intake of a high-calorie diet (HCD). Although numerous T2DM murine models have been developed using C57BL/6 mice, BALB/c mice typically fail to develop the disease under the same conditions. We hypothesized that diets optimized for C57BL/6 mice may be insufficient to induce T2DM in BALB/c mice. Female BALB/c and C57BL/6 mice (

Indexed as

animal modelBALB/c miceC57BL/6 micehigh-calorie diettype 2 diabetes mellitus

Identifiers

PMID41594843
PMCPMC12838287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.