Evidence map›Paper›PMID 41594740›Full record

ArticleBrain sciences2025

Predictors, Complications, and Clinical Outcomes of Cerebrospinal Fluid Leak Post Endoscopic Endonasal Skull Base Surgery.

Alejandro Vargas-Moreno, Sami Khairy, Mouaz Saymeh, Damanpreet Kaur Lang, Sara K Dabbour, Jessica Rabski, Shaun Kilty, Fahad Alkherayf

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alejandro Vargas-MorenoDivision of Neurosurgery, Department of Surgery, The Ottawa Hospital, Ottawa, ON K1Y 4E9, Canada.
Sami KhairyDivision of Neurosurgery, Department of Surgery, The Ottawa Hospital, Ottawa, ON K1Y 4E9, Canada.ORCID 0000-0002-3120-3412
Mouaz SaymehThe Ottawa Hospital Research Institute, The Ottawa Hospital, Civic Campus, 1053 Carling Ave., Ottawa, ON K1Y 4E9, Canada.
Damanpreet Kaur LangThe Ottawa Hospital Research Institute, The Ottawa Hospital, Civic Campus, 1053 Carling Ave., Ottawa, ON K1Y 4E9, Canada.
Sara K DabbourCollege of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.
Jessica RabskiDivision of Neurosurgery, Department of Surgery, The Ottawa Hospital, Ottawa, ON K1Y 4E9, Canada.
Shaun KiltyDepartment of Otolaryngology-Head and Neck Surgery, University of Ottawa, Ottawa, ON K1Y 1J8, Canada.
Fahad AlkherayfDivision of Neurosurgery, Department of Surgery, The Ottawa Hospital, Ottawa, ON K1Y 4E9, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative cerebrospinal fluid (CSF) leakage remains a significant complication following endoscopic endonasal skull base surgery (EES), leading to increased morbidity. This study aimed to identify factors and interventions predicting postoperative CSF leaks after EES for intradural skull base tumors and their clinical outcomes.

methodsWe retrospectively reviewed data from 542 patients who underwent EES for intradural skull base pathology at the Ottawa Hospital between October 2001 and October 2023. Patient demographics, pre-operative, intraoperative (including reconstruction type), postoperative data, and patient outcomes were collected.

resultsA total of 40 patients (7.4%) developed a postoperative CSF leak. The highest rate was in patients with suprasellar lesions (5.9%), followed by anterior cranial fossa lesions (1.1%). Significant predictors included a higher mean Body Mass Index (BMI) (30.4 vs. 26.1,

conclusionThis retrospective study shows that higher preoperative BMI is associated with a significant risk of postoperative CSF leaks after EES. Conversely, using a pedicled vascularized flap reduces the risk. Postoperative CSF leaks are linked to increased morbidity, including diabetes insipidus and sepsis, prolonged hospitalization, and higher readmission rates.

Indexed as

CSF leakendoscopic endonasal surgeryintraoperative monitoringpedicled vascularized flapskull base tumor

Identifiers

PMID41594740
PMCPMC12839152

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.