Evidence map›Paper›PMID 41594731›Full record

ArticleBrain sciences2025

Computational Advances in Taste Perception: From Ion Channels and Taste Receptors to Neural Coding.

Vladimir A Lazovsky, Sergey V Stasenko, Roman K Khismatullin, Victor B Kazantsev

Abstract read
In one paragraph

Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vladimir A LazovskyMoscow Center for Advanced Studies, Kulakova Str. 20, 123592 Moscow, Russia.
Sergey V StasenkoMoscow Center for Advanced Studies, Kulakova Str. 20, 123592 Moscow, Russia.ORCID 0000-0002-3032-5469
Roman K KhismatullinMoscow Center for Advanced Studies, Kulakova Str. 20, 123592 Moscow, Russia.
Victor B KazantsevMoscow Center for Advanced Studies, Kulakova Str. 20, 123592 Moscow, Russia.ORCID 0000-0002-2881-6648

Funding

the Russian Science Foundation 23-11-00134
6 · The paper itself

Abstract

We present a multiscale model of taste that is both biophysically faithful and computationally efficient, enabling end-to-end simulation from receptor transduction to network-level coding. The novelty lies in coupling Hodgkin-Huxley taste receptor cells with Goldman-Hodgkin-Katz ion currents and modality-specific receptors (T1R/T2R, ENaC), to an Izhikevich spiking network equipped with realistic glutamatergic synapses and spike-timing-dependent plasticity. Training combines spike synchrony and a genetic approach in order to reach both globally optimized network structure and biomorphic synaptic plasticity. This hybrid design yields distinct, sparse spiking "fingerprints" for taste qualities and mixtures, and provides a practical foundation for neuromorphic gustatory sensors that require real-time, energy-efficient operation.

Indexed as

biophysical neuron modelsgustatory systemmultiscale neural codingspike-timing-dependent plasticity

Identifiers

PMID41594731
PMCPMC12839392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.