ArticleBiomolecules2026
2-Arylbenzofurans as Selective Cholinesterase Inhibitors: Design, Synthesis, and Evaluation as Alzheimer's Disease Agents.
Giovanna Lucia Delogu, Michela Begala, Manuel Novás, Maria João Matos, Franca Piras, Sonia Floris, Francesca Pintus, Michele Mancinelli, Benedetta Era, Antonella Fais
Abstract read
In one paragraphArticle in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Giovanna Lucia DeloguDepartment of Live and Environmental Sciences, University of Cagliari, Cittadella Universitaria, SS 554, Km 4.5, 09042 Monserrato, Italy.ORCID 0000-0003-0307-1544 Michela BegalaDepartment of Live and Environmental Sciences, University of Cagliari, Cittadella Universitaria, SS 554, Km 4.5, 09042 Monserrato, Italy.ORCID 0000-0002-8213-2335 Manuel NovásDepartamento de Química Orgánica, Facultad de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.ORCID 0009-0008-4678-1339 Maria João MatosDepartamento de Química Orgánica, Facultad de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.ORCID 0000-0002-3470-8299 Franca PirasDepartment of Biomedical Science, University of Cagliari, Cittadella Universitaria, SS 554, Km 4.5, 09042 Monserrato, Italy.ORCID 0000-0002-9010-1926 Sonia FlorisDepartment of Live and Environmental Sciences, University of Cagliari, Cittadella Universitaria, SS 554, Km 4.5, 09042 Monserrato, Italy.
Francesca PintusDepartment of Live and Environmental Sciences, University of Cagliari, Cittadella Universitaria, SS 554, Km 4.5, 09042 Monserrato, Italy.ORCID 0000-0003-2350-7966 Michele MancinelliDepartment of Industrial Chemistry "Toso Montanari", University of Bologna, Viale del Risorgimento, 4, 40136 Bologna, Italy.ORCID 0000-0002-8499-5265 Benedetta EraDepartment of Live and Environmental Sciences, University of Cagliari, Cittadella Universitaria, SS 554, Km 4.5, 09042 Monserrato, Italy.ORCID 0000-0002-4154-9740 Antonella FaisDepartment of Live and Environmental Sciences, University of Cagliari, Cittadella Universitaria, SS 554, Km 4.5, 09042 Monserrato, Italy.ORCID 0000-0002-3009-4226 Funding
Fondazione di Sardegna F73C23001850007Xunta da Galicia Grant ED431B 2025/15
6 · The paper itselfAbstract
New arylbenzofuran derivatives were designed, synthesized, and evaluated as potential inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Five hybrid compounds (
Indexed as
Alzheimer DiseaseBenzofuransCholinesterase InhibitorsDrug DesignAcetylcholinesteraseAntioxidantsButyrylcholinesteraseCell Line, TumorHumansMolecular Docking SimulationStructure-Activity RelationshipAcetylcholinesteraseAntioxidantsBenzofuransButyrylcholinesteraseCholinesterase Inhibitors2-arylbenzofuranscholinesterase inhibitorsdocking studies
Identifiers
PMID41594719
PMCPMC12839115
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