Design and Physicochemical Characterization of Hybrid PLGA-Curcumin/Carbon Dot Nanoparticles for Sustained Galantamine Release: A Proof-of-Concept Study.

Christina Samiotaki, Stavroula Nanaki, Rizos Evangelos Bikiaris, Evi Christodoulou, George Z Kyzas, Panagiotis Barmpalexis, Dimitrios N Bikiaris

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Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Christina SamiotakiLaboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.

Stavroula NanakiLaboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.

Rizos Evangelos BikiarisHephaestus Laboratory, School of Chemistry, Faculty of Sciences, Democritus University of Thrace, 654 04 Kavala, Greece.

Evi ChristodoulouLaboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.ORCID 0000-0003-2730-0778

George Z KyzasHephaestus Laboratory, School of Chemistry, Faculty of Sciences, Democritus University of Thrace, 654 04 Kavala, Greece.ORCID 0000-0003-1516-3761

Panagiotis BarmpalexisLaboratory of Pharmaceutical Technology, Department of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.ORCID 0000-0002-6765-512X

Dimitrios N BikiarisLaboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.ORCID 0000-0001-8458-4952

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study reports the design and physicochemical characterization of a hybrid nanoparticle system for the potential intranasal delivery of galantamine (GAL), aimed at improving its bioavailability. Carbon dots (CDs) were used to load GAL, enhancing its dissolution and stability, and were subsequently incorporated into a poly(lactic-co-glycolic acid)-curcumin (PLGA-Cur) conjugate matrix. The successful formation of the PLGA-Cur conjugate was verified via

Indexed as

Carbon Quantum DotsCurcuminGalantamineNanoparticlesPolylactic Acid-Polyglycolic Acid CopolymerCarbonDelayed-Action PreparationsDrug CarriersDrug LiberationParticle SizeProof of Concept StudySpectroscopy, Fourier Transform InfraredCarbonCurcuminDelayed-Action PreparationsDrug CarriersGalantaminePolylactic Acid-Polyglycolic Acid Copolymercarbon dotscurcumingalantamineintranasal deliverypoly (lactic-co-glycolic acid)

Identifiers

PMID41594716

DOI10.3390/biom16010176

PMCPMC12839151

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.