Cyclic-FMN Is a Detectable, Putative Intermediate of FAD Metabolism.

Luxene Belfleur, Juha P Kallio, Wito Richter, Natalie R Gassman, Mathias Ziegler, Marie E Migaud

Abstract read

In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Luxene BelfleurMitchell Cancer Institute, Mass Spectrometry Core Facility, University of South Alabama, Mobile, AL 36604, USA.

Juha P KallioDepartment of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway.ORCID 0000-0003-3092-4012

Wito RichterDepartment of Biochemistry, University of South Alabama, Mobile, AL 36688, USA.ORCID 0000-0001-5588-9060

Natalie R GassmanDepartment of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-8488-2332

Mathias ZieglerDepartment of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway.ORCID 0000-0001-6961-2396

Marie E MigaudMitchell Cancer Institute, Mass Spectrometry Core Facility, University of South Alabama, Mobile, AL 36604, USA.ORCID 0000-0002-9626-2405

Funding

NIH HHS 1R21AT009908-01Research council of Norway grant #325172

6 · The paper itself

Abstract

Free flavin adenine dinucleotide (FAD) is metabolized to flavin mononucleotide (FMN) and adenine monophosphate (AMP) by hydrolases and to 4',5'-cyclic phosphoriboflavin (cFMN) and AMP by the triose kinase FMN cyclase (TKFC). Yet, the lack of analytical standards for cFMN might have resulted in the incidence of cFMN in biological specimens being underreported. To address this shortcoming, cFMN was synthesized from either FMN or FAD. The optimization of the FAD to cFMN reaction conditions revealed that an equimolar ratio of ZnSO

Indexed as

Flavin-Adenine DinucleotideFlavin MononucleotideAnimalsRiboflavinFlavin-Adenine DinucleotideFlavin MononucleotideRiboflavincyclic-FMNcyclic nucleotidedivalent cationsFADriboflavinvitamin B2

Identifiers

PMID41594715

DOI10.3390/biom16010175

PMCPMC12838640

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.