ArticleBiomolecules2026
The Cap-Independent Translation of Survivin 5'UTR and HIV-1 IRES Sequences Is Inhibited by Oxidative Stress Produced by
Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSurvivin is an anti-apoptotic protein highly expressed during embryonic development and, in adults, mainly in the gastrointestinal epithelium. Its levels decrease in human gastric tissue and cultured cells upon exposure to
objectiveWe aimed to investigate the role of cap-independent translation driven by the Survivin 5' untranslated region (5'UTR) in response to METHODOLOGY: Human cell lines (AGS, GES-1, HeLa, HEK293T) were used alongside bicistronic and monocistronic (Firefly/Renilla luciferases) reporter assays to assess short and long variants of the Survivin 5'UTR and HIV-1 internal ribosome entry site (IRES) sequences. Additional methods included in vitro transcription/translation, RT-qPCR, agarose gel electrophoresis, Western blotting, coupled/uncoupled translation assays, and siRNA silencing.
resultsThe short variant of the Survivin 5' UTR supported cap-independent translation, like the HIV-1 IRES. Notably,
conclusionThe Survivin 5'UTR exhibits cap-independent translation activity that is inhibited by
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