Evidence map›Paper›PMID 41594671›Full record

ArticleBiomolecules2026

Protective Effects of Cord Blood Serum (CBS) on Retinal Pigment Epithelium (ARPE-19) and Retinal Photoreceptor-like (661W) Cell Line Viability Under In Vitro Oxidative Stress.

Ilenia Motta, Francesca Corsi, Ilaria Piano, Silvia Bisti, Elisa Bergantin, Marina Buzzi, Maria Claudia Gargini, Piera Versura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ilenia MottaAlma Mater Institute on Healthy Planet, Alma Mater Studiorum University of Bologna, Via Massarenti 11, 40138 Bologna, Italy.
Francesca CorsiDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.
Ilaria PianoDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-5073-7583
Silvia BistiNational Institute of Biostructure and Biosystem (INBB), V.le Medaglie D'Oro 305, 00136 Roma, Italy.ORCID 0000-0003-4157-111X
Elisa BergantinIRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Massarenti 9, 40138 Bologna, Italy.
Marina BuzziIRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Massarenti 9, 40138 Bologna, Italy.ORCID 0000-0002-3711-5886
Maria Claudia GarginiDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.
Piera VersuraIRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Massarenti 9, 40138 Bologna, Italy.ORCID 0000-0002-2951-5337

Funding

Fondazione Carisbo, Bologna 2017/0330 to PV
6 · The paper itself

Abstract

Neuroprotection represents a promising approach for mitigating retinal degeneration. Cord blood serum (CBS), rich in trophic factors such as the brain-derived neurotrophic factor (BDNF), has shown therapeutic potential for ocular surface diseases; however, its role in retinal neuroprotection remains underexplored. This study evaluates the protective effects of CBS on retinal pigment epithelium (ARPE-19) and photoreceptor-like (661W) cells exposed to oxidative stress. Cells were cultured in media supplemented with fetal bovine serum (FBS) or CBS with either high (CBS-H) or low (CBS-L) BDNF content. Oxidative stress was induced using hydrogen peroxide (H

Indexed as

Fetal BloodOxidative StressRetinal Pigment EpitheliumSerumAnimalsBrain-Derived Neurotrophic FactorCell LineCell SurvivalHumansHydrogen PeroxideMitochondriaZonula Occludens-1 ProteinBrain-Derived Neurotrophic FactorHydrogen PeroxideTJP1 protein, humanZonula Occludens-1 Proteinbrain-derived neurotrophic factor (BDNF)cord blood serumneuroprotectionoxidative stressretina photoreceptor-like (661W) cellsretina pigment epithelium (ARPE-19) cells

Identifiers

PMID41594671
PMCPMC12838533

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.