Evidence map›Paper›PMID 41594664›Full record

ArticleBiomolecules2026

Human Alpha-1 Antitrypsin Suppresses Melanoma Growth by Promoting Tumor Differentiation and CD8

Takeshi Yamauchi, Yuchun Luo, Dinoop Ravindran Menon, Kasey Couts, Sana Khan, Aanchal Goel, Charles A Dinarello, Zili Zhai, Mayumi Fujita

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Takeshi YamauchiDepartment of Dermatology, University of California San Diego, La Jolla, CA 92037, USA.ORCID 0000-0002-7050-7531
Yuchun LuoDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Dinoop Ravindran MenonDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-6335-9227
Kasey CoutsDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-2088-2229
Sana KhanDepartment of Dermatology, University of California San Diego, La Jolla, CA 92037, USA.ORCID 0009-0003-1172-8312
Aanchal GoelDepartment of Dermatology, University of California San Diego, La Jolla, CA 92037, USA.ORCID 0009-0008-8064-1559
Charles A DinarelloDepartment of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Zili ZhaiDepartment of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0001-5164-3696
Mayumi FujitaDepartment of Dermatology, University of California San Diego, La Jolla, CA 92037, USA.ORCID 0000-0002-1498-1925

Funding

The role of IL-37 in human regulatory T cells, SupplementR01AI156534 · NIAID · UNIVERSITY OF COLORADO DENVER · PI FUJITA, MAYUMI · 2021 to 2025
$3.0M
Modulation of Inflammasome-mediated cytokine activation by EGCG in human melanomaR01CA197919 · NCI · UNIVERSITY OF COLORADO DENVER · PI FUJITA, MAYUMI · 2016 to 2020
$1.9M
BLRD VA I01 BX001228BLRD VA I01 BX006598NCI NIH HHS R01 CA197919NIAID NIH HHS R01 AI156534NIH/NCI R01 CA197919Veterans Affairs Merit Review Award 5I01BX001228
6 · The paper itself

Abstract

Alpha-1 antitrypsin (AAT) is a serine protease inhibitor with potent anti-inflammatory and immunomodulatory properties, but its role in cancer is context-dependent across tumor types. We integrated transcriptomic analyses of human melanoma cohorts, in vivo studies using AAT-transgenic (hAAT-TG) mice, and in vitro assays in murine and human melanoma cells to define the biological functions of AAT in melanoma.

Indexed as

alpha 1-AntitrypsinCD8-Positive T-LymphocytesImmunity, CellularMelanomaAnimalsCell DifferentiationCell Line, TumorHumansMiceMice, Transgenicalpha 1-AntitrypsinSERPINA1 protein, humanalpha-1 antitrypsinimmunitymelanin pigmentationmelanomatumor microenvironment

Identifiers

PMID41594664
PMCPMC12838898

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.