Evidence map›Paper›PMID 41594617›Full record

ArticleBiomolecules2026

Crystalline Insights into Nasal Mucosa Inflammation and Remodeling: Unveiling Role of Galectin-10.

Olga Maria Manna, Velia Malizia, Andrea Perri, Stefania La Grutta, Alberto Fucarino, Domiziana Picone, Mirella Profita, Fabio Bucchieri, Francesca Rappa, Rosalia Gagliardo

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Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Olga Maria MannaPathologic Anatomy Unit, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90127 Palermo, Italy.
Velia MaliziaInstitute of Translational Pharmacology, Italian National Research Council, 90146 Palermo, Italy.
Andrea PerriInstitute of Translational Pharmacology, Italian National Research Council, 90146 Palermo, Italy.ORCID 0009-0006-1026-8117
Stefania La GruttaInstitute of Translational Pharmacology, Italian National Research Council, 90146 Palermo, Italy.ORCID 0000-0001-8026-0715
Alberto FucarinoDepartment of Theoretical and Applied Sciences, eCampus University, 22060 Novedrate, Italy.ORCID 0000-0001-8958-525X
Domiziana PiconeDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University of Palermo, 90127 Palermo, Italy.ORCID 0009-0004-0553-536X
Mirella ProfitaInstitute of Translational Pharmacology, Italian National Research Council, 90146 Palermo, Italy.ORCID 0000-0002-7821-8283
Fabio BucchieriDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University of Palermo, 90127 Palermo, Italy.
Francesca RappaInstitute of Translational Pharmacology, Italian National Research Council, 90146 Palermo, Italy.ORCID 0000-0001-6610-5268
Rosalia GagliardoInstitute of Translational Pharmacology, Italian National Research Council, 90146 Palermo, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGalectin-10 (Gal-10), the main constituent of Charcot-Leyden crystals, is a recognized marker of eosinophilic inflammation, yet its role in nasal mucosal remodeling in Seasonal Allergic Rhinitis (SAR) remains poorly defined.

methodsGal-10, IL-5, MUC5AC, and IFN-γ were analyzed in Nasal lavage (NL) samples from children with SAR by ELISA. Unsupervised clustering and discriminant analyses were applied. The functional effects of Gal-10 were investigated ex vivo using a 3D epithelial-mesenchymal trophic unit (EMTU) model stimulated with NL containing high, low, or depleted Gal-10 levels. EMT (epithelial-mesenchymal transition) markers (vimentin, E-cadherin, SNAIL1) and MUC5AC secretion were assessed by immunohistochemistry, Western blot, and ELISA.

resultsGal-10 levels in NL positively correlated with IL-5 and MUC5AC and inversely with IFN-γ. Clustering analysis identified distinct SAR endotypes, with Gal-10 showing the highest discriminative power. In the 3D EMTU model, high Gal-10 NL induced increased vimentin and SNAIL1 expression and enhanced MUC5AC secretion, effects attenuated after Gal-10 depletion.

conclusionsGal-10 is associated with Th2-type inflammation, mucus hypersecretion, and early epithelial-mesenchymal transition in pediatric SAR, supporting its role as a mediator of nasal mucosal remodeling and a potential therapeutic target.

Indexed as

GalectinsInflammationNasal MucosaChildEpithelial-Mesenchymal TransitionFemaleHumansInterferon-gammaInterleukin-5MaleMucin 5ACNasal Lavage FluidGalectinsInterferon-gammaInterleukin-5MUC5AC protein, humanMucin 5ACepithelial–mesenchymal transition (EMT)Galectin-10inflammationnasal mucosaremodelingSeasonal Allergic Rhinitis (SAR)

Identifiers

PMID41594617
PMCPMC12838890

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.