Novel tRNA Synthetase Inhibitors Increase Healthspan, Lifespan, and Autophagic Flux in

Olivia C Heath, Madison P Otero, Alexander T Achusim, Dorothy S Karr, Antonio W Leger, Mark A McCormick

Abstract read

In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Olivia C HeathDepartment of Biochemistry and Molecular Biology, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

Madison P OteroDepartment of Biochemistry and Molecular Biology, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.ORCID 0009-0002-2669-2263

Alexander T AchusimDepartment of Biochemistry and Molecular Biology, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

Dorothy S KarrDepartment of Biochemistry and Molecular Biology, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

Antonio W LegerDepartment of Biochemistry and Molecular Biology, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

Mark A McCormickDepartment of Biochemistry and Molecular Biology, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

Funding

American Federation for Aging Research Reboot AwardNIH HHS 1P20GM121176-21NIH HHS 1R01AG070776-24Norn Group Longevity Impetus Grant

6 · The paper itself

Abstract

We previously demonstrated that the tRNA synthetase inhibitors mupirocin and borrelidin extend lifespan in

Indexed as

Amino Acyl-tRNA SynthetasesAutophagyCaenorhabditis elegansEnzyme InhibitorsLongevityActivating Transcription Factor 4AnimalsCaenorhabditis elegans ProteinsPiperidinesQuinazolinonesActivating Transcription Factor 4Amino Acyl-tRNA SynthetasesCaenorhabditis elegans ProteinsEnzyme InhibitorshalofuginonePiperidinesQuinazolinonesATF-4ATF4autophagyGcn4healthspantRNA synthetase

Identifiers

PMID41594613

DOI10.3390/biom16010073

PMCPMC12839378

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.