Evidence map›Paper›PMID 41594602›Full record

ArticleBiomolecules2025

Celastrol Activates HSF1 to Enhance Regulatory T Cells Function and Ameliorate Intestinal Inflammation.

Kibrom M Alula, Colm B Collins, Tom T Nguyen, Carol M Aherne, Paul Jedlicka, Edwin F de Zoeten

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kibrom M AlulaMucosal Inflammation Program, University of Colorado School of Medicine, Aurora, CO 80045, USA.ORCID 0000-0002-1960-7617
Colm B CollinsMucosal Inflammation Program, University of Colorado School of Medicine, Aurora, CO 80045, USA.ORCID 0000-0002-3946-1782
Tom T NguyenMucosal Inflammation Program, University of Colorado School of Medicine, Aurora, CO 80045, USA.ORCID 0000-0003-4222-4099
Carol M AherneMucosal Inflammation Program, University of Colorado School of Medicine, Aurora, CO 80045, USA.ORCID 0000-0001-5653-9003
Paul JedlickaDepartment of Pathology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Edwin F de ZoetenMucosal Inflammation Program, University of Colorado School of Medicine, Aurora, CO 80045, USA.ORCID 0000-0002-0946-9759

Funding

microRNA-dependent regulation of intestinal T-cells²R01DK111856 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI DE ZOETEN, EDWIN FULCO · 2018 to 2022
$1.7M
Selective MicoRNA modification to enhance regulatory T cell function in IBDK01DK099403 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI COLLINS, COLM · 2013 to 2017
$678k
Crohn's and Colitis Foundation 253596Crohn's and Colitis Foundation 253618NIDDK NIH HHS K01DK099403NIDDK NIH HHS R01 DK111856NIDDK NIH HHS R01DK111856
6 · The paper itself

Abstract

Inflammatory Bowel Disease (IBD) is a chronic inflammatory condition resulting from dysregulation of the intestinal immune system. CD4

Indexed as

Heat Shock Transcription FactorsInflammatory Bowel DiseasesPentacyclic TriterpenesT-Lymphocytes, RegulatoryAnimalsColitisDisease Models, AnimalInflammationIntestinesMiceMice, Inbred C57BLTriterpenescelastrolHeat Shock Transcription FactorsHsf1 protein, mousePentacyclic TriterpenesTriterpenescelastrolheat shock factor 1inflammatory bowel diseaseregulatory T cell

Identifiers

PMID41594602
PMCPMC12839249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.