ArticleBiomolecules2025
Steric and Electronic Effects in the Enzymatic Catalysis of Choline-TMA Lyase.
Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
An important microbial enzymatic pathway in the gut is choline/phosphatidylcholine degradation in which intestinal microbes utilize dietary choline to produce TMA via the choline utilization cluster polypeptide C (CutC) enzyme, a member of the glycyl radical enzyme family. Our goal in this theoretical work was to study the reaction mechanism and elucidate how the enzyme environment (steric and electronic) modulates the reaction path. Dissecting the effect of the enzyme environment on the reaction mechanism and shedding light on how steric and electronic effects affect the reaction path is an insightful and significant contribution of this work. Our theoretical results suggest that the final product of enzyme catalysis might be carbinolamine and not TMA and acetaldehyde. In addition, we found out that Glu
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