Development and Characterization of Cannabidiol Self-Emulsifying Drug Delivery System: In Vitro and In Vivo Evaluation.

Nourhan Mostafa, Iman E Taha, Noha M Abourobe, Eman A Ashour

Abstract read

In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nourhan MostafaDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, University, MS 38677, USA.ORCID 0009-0004-6290-8599

Iman E TahaDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, University, MS 38677, USA.

Noha M AbourobeDepartment of Pharmaceutics, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.

Eman A AshourDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, University, MS 38677, USA.ORCID 0000-0001-9013-1327

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cannabidiol (CBD) is a non-psychoactive phyto-cannabinoid with numerous pharmacological potentials. CBD is a lipophilic drug with poor and varied bioavailability due to its low water solubility and extensive first-pass metabolism, and it is highly affected by the presence of food. A self-emulsifying drug delivery system (SEDDS) was developed to improve the aqueous solubility and oral bioavailability of CBD. The formulation strategy involved incorporating excipients that maintain drug solubility under both fasted and fed conditions, while potentially mitigating first-pass metabolism to enhance overall bioavailability and dose proportionality. Caproyl

Indexed as

CannabidiolDrug Delivery SystemsEmulsifying AgentsAdministration, OralAnimalsBiological AvailabilityDrug LiberationEmulsionsEthylene GlycolsExcipientsMalePolysorbatesSolubilitySurface-Active AgentsCannabidiolcarbitolEmulsifying AgentsEmulsionsEthylene GlycolsExcipientsPolysorbatesSurface-Active Agentsbioavailabilitycannabidiol (CBD)endocannabinoid system (ECS)inhibition effectlipid-based drug delivery system (LBDDS)non-ionic surfactantself-emulsifying drug delivery system (SEDDS)

Identifiers

PMID41594563

DOI10.3390/biom16010021

PMCPMC12838755

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.