Evidence map›Paper›PMID 41594443›Full record

ArticleAnimals : an open access journal from MDPI2026

Testicular Gap (

Sandra Goericke-Pesch, Lena Röhrs, Sven Wallrabenstein, Agnete Frimødt Rønnow, Daniela Fietz, Ralph Brehm, Marion Langeheine, Axel Wehrend, Bernd Hoffmann, Hanna Körber and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sandra Goericke-PeschClinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Justus-Liebig-University Giessen, Frankfurter Str. 106, 35392 Giessen, Germany.ORCID 0000-0002-4327-9780
Lena RöhrsClinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Justus-Liebig-University Giessen, Frankfurter Str. 106, 35392 Giessen, Germany.
Sven WallrabensteinClinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Justus-Liebig-University Giessen, Frankfurter Str. 106, 35392 Giessen, Germany.
Agnete Frimødt RønnowDepartment of Veterinary Sciences, Section for Veterinary Reproduction and Obstetrics, Faculty of Health and Medical Sciences, University of Copenhagen, Højbakkegård 5, 2630 Tåstrup, Denmark.
Daniela FietzInstitute of Veterinary Anatomy, Histology and Embryology, Justus-Liebig-University Giessen, Frankfurter Str. 94, 35392 Giessen, Germany.ORCID 0000-0002-7945-1810
Ralph BrehmInstitute of Anatomy, University of Veterinary Medicine Hannover, Bischofsholer Damm 15, 30173 Hannover, Germany.ORCID 0000-0002-0489-7594
Marion LangeheineInstitute of Anatomy, University of Veterinary Medicine Hannover, Bischofsholer Damm 15, 30173 Hannover, Germany.ORCID 0000-0002-3842-4867
Axel WehrendClinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Justus-Liebig-University Giessen, Frankfurter Str. 106, 35392 Giessen, Germany.ORCID 0000-0002-3313-4852
Bernd HoffmannClinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Justus-Liebig-University Giessen, Frankfurter Str. 106, 35392 Giessen, Germany.
Hanna KörberUnit for Reproductive Medicine-Clinic for Small Animals, University of Veterinary Medicine Hannover, Foundation, Bünteweg 15, 30559 Hannover, Germany.ORCID 0000-0003-0842-6615
Eva-Maria PackeiserUnit for Reproductive Medicine-Clinic for Small Animals, University of Veterinary Medicine Hannover, Foundation, Bünteweg 15, 30559 Hannover, Germany.ORCID 0000-0001-6694-3851

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Following the downregulation of testicular endocrine and germinative function by slow-release gonadotropin-releasing hormone (GnRH)-agonist implants, testicular functions are quickly restored after implant removal. As an intact blood-testis barrier (BTB) is crucial for normal spermatogenesis and its integrity is FSH- and androgen-dependent, alterations in the BTB gene and protein expressions during downregulation and subsequent restart seem inevitable. We investigated

Indexed as

blood–testis barrierclaudinconnexin 43dogGnRH-agonistoccludin

Identifiers

PMID41594443
PMCPMC12837560

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.