Evidence map›Paper›PMID 41594428›Full record

ReviewAnimals : an open access journal from MDPI2026

Nitrogen Source-Carbohydrate Synchronization in Ruminant Nutrition: A Systematic Review.

Leilson Rocha Bezerra, Juliana Paula Felipe de Oliveira, Antônio Fernando de Melo Vaz, Kevily Henrique de Oliveira Soares de Lucena, Lucas de Souza Barros, Yuri Martins de Andrade Fortunato, Severino Gonzaga Neto, Elzania Sales Pereira, Ronaldo Lopes Oliveira, José Morais Pereira Filho

Abstract readReview
In one paragraph

Review in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Leilson Rocha BezerraDepartment of Animal Science, Federal University of Campina Grande, Patos 58708110, Paraíba, Brazil.ORCID 0000-0002-8815-3946
Juliana Paula Felipe de OliveiraDepartment of Animal Science, Federal University of Sergipe, Nossa Senhora da Gloria 49680000, Sergipe, Brazil.ORCID 0000-0001-9005-5272
Antônio Fernando de Melo VazDepartment of Animal Science, Federal University of Campina Grande, Patos 58708110, Paraíba, Brazil.ORCID 0000-0002-9632-1268
Kevily Henrique de Oliveira Soares de LucenaDepartment of Animal Science, Federal University of Campina Grande, Patos 58708110, Paraíba, Brazil.ORCID 0000-0002-4885-2945
Lucas de Souza BarrosDepartment of Animal Science, Federal University of Campina Grande, Patos 58708110, Paraíba, Brazil.ORCID 0000-0001-9655-7265
Yuri Martins de Andrade FortunatoDepartment of Animal Science, Federal University of Campina Grande, Patos 58708110, Paraíba, Brazil.ORCID 0000-0002-3098-566X
Severino Gonzaga NetoDepartment of Animal Science, Federal University of Paraíba, Areia 60356000, Paraíba, Brazil.ORCID 0000-0003-4220-4071
Elzania Sales PereiraDepartment of Animal Science, Federal University of Ceara, Fortaleza 60356000, Ceara, Brazil.ORCID 0000-0003-2003-5203
Ronaldo Lopes OliveiraDepartment of Animal Science, Federal University of Bahia, Salvador 40170110, Bahia, Brazil.ORCID 0000-0001-5887-4753
José Morais Pereira FilhoDepartment of Animal Science, Federal University of Campina Grande, Patos 58708110, Paraíba, Brazil.ORCID 0000-0002-9683-4565

Funding

Fundação de Apoio à Pesquisa do Estado da Paraíba PRONEX 033/2023
6 · The paper itself

Abstract

The synchronization between nitrogen sources and carbohydrate fractions represents a critical factor for optimizing microbial protein synthesis and overall ruminant performance. This systematic review, conducted according to PRISMA 2020 guidelines, comprehensively evaluated the interactions between different nitrogen sources (true protein, urea, controlled-release urea, and bypass amino acids) and carbohydrate fractions (rapidly degrading soluble, slowly degrading soluble, fibrous, non-fibrous, and Van Soest fractions) in ruminant nutrition. A comprehensive search across PubMed, ScienceDirect, Web of Science, and Scopus databases identified 1855 records, of which 164 studies met the eligibility criteria for qualitative synthesis and 89 for quantitative meta-analysis. The review reveals that synchronization effectiveness varies significantly depending on the nitrogen source-carbohydrate combination, with controlled-release urea showing superior synchrony with slowly degrading carbohydrates, while conventional urea performs better with rapidly degrading sources. Meta-analytical results indicate that optimal nitrogen-carbohydrate synchronization can improve microbial protein synthesis by 18-34%, reduce urinary nitrogen excretion by 12-28%, and enhance feed efficiency by 8-15%. These findings provide evidence-based recommendations for precision nutrition strategies in ruminant production systems.

Indexed as

bypass amino acidscontrolled-release ureanitrogen–carbohydrate synchronyslow-release urea

Identifiers

PMID41594428
PMCPMC12838081

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.