ArticleAnimals : an open access journal from MDPI2026
Dexmedetomidine Versus Clonidine as an Adjuvant to Lidocaine Spinal Anesthesia in an Ovine Experimental Model.
Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
8 authors.
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Abstract
Sheep are routinely used as orthopedic models due to their similarities to human joints. Spinal anesthesia provides adequate analgesia for these procedures, and its duration can be enhanced with adjuvant drugs. Clonidine is commonly used in human spinal anesthesia, while dexmedetomidine is a newer and more selective α-2 agonist. This study compared the duration and analgesic effect of these two drugs as adjuvants in spinal anesthesia. Thirty-nine sheep undergoing experimental pelvic limb cartilage damage surgery were enrolled. Animals were sedated with diazepam (0.4 mg kg
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