Evidence map›Paper›PMID 41594316›Full record

ReviewDiagnostics (Basel, Switzerland)2026

Intra-Arterial Radioligand Therapy in Brain Cancer: Bridging Nuclear Medicine and Interventional Neuroradiology.

Federico Sabuzi, Luca Filippi, Mariafrancesca Trulli, Fabio Domenici, Francesco Garaci, Valerio Da Ros

Abstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Federico SabuziDepartment of Biomedicine and Prevention, University Hospital of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.ORCID 0000-0002-8284-755X
Luca FilippiDepartment of Biomedicine and Prevention, University Hospital of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.ORCID 0000-0003-4423-5496
Mariafrancesca TrulliDepartment of Biomedicine and Prevention, University Hospital of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.ORCID 0009-0007-3374-7847
Fabio DomeniciDepartment of Chemical Science and Technologies, University of Rome "Tor Vergata", Via della Ricerca Scientifica 1, 00133 Rome, Italy.ORCID 0000-0001-6776-2737
Francesco GaraciDepartment of Biomedicine and Prevention, University Hospital of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.
Valerio Da RosDepartment of Biomedicine and Prevention, University Hospital of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.ORCID 0000-0001-7167-7594

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recurrent brain tumors-including high-grade gliomas, brain metastases, and aggressive meningiomas-continue to carry a poor prognosis, with high mortality despite therapeutic advances. The aim of this narrative review is to summarize and critically discuss the current evidence on the role of intra-arterial radioligand therapy (RLT) in the treatment of recurrent brain tumors. RLT, a targeted form of radionuclide therapy, has gained increasing attention for its potential theranostic applications in neuro-oncology. A literature search was conducted using PubMed and Scopus, including clinical studies evaluating intra-arterial radioligand delivery in central nervous system tumors. Recent research has explored intra-arterial administration of radioligands targeting somatostatin receptors and prostate-specific membrane antigen (PSMA). Somatostatin receptors are overexpressed in meningiomas, while PSMA is highly expressed in the neovasculature of glioblastomas and brain metastases; both targets can be addressed using lutetium-177 (

Indexed as

brain tumorsglioblastomainterventional neuroradiologymeningiomaneuro-oncologyPET/CTradioligand therapy

Identifiers

PMID41594316
PMCPMC12839570

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.