ArticleDiagnostics (Basel, Switzerland)2026
Unifying Serum Creatinine and Urine Output in a Single On-Time AKI Severity Criterion: Is It All About the Rate of Creatinine Being Excreted by the Kidneys?
Article in Diagnostics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serum creatinine (sCr) and urine output (UO) have long been considered the cornerstones of acute kidney injury (AKI) severity criteria. Many articles were previously published discussing the prognostic relevance of fulfilling either one or both AKI criteria. However, sCr and UO must not be considered independent variables because they are physiologically linked despite having distinct chronologies as AKI markers. An increase in sCr is a late manifestation of decreased renal function and body creatinine accumulation and not an on-time surrogate for a decreasing glomerular filtration rate. On the other hand, oliguria is not a single entity, and its interpretation relies on urine's biochemical composition as well as its threshold pathological output value, which is somewhat controversial. In the present article, the current practice of evaluating sCr and UO separately is questioned and the idea that they can eventually be considered different expressions of the same variable of interest (the urine creatinine excretion) is highlighted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.