Evidence map›Paper›PMID 41594099›Full record

ArticleAntibiotics (Basel, Switzerland)2026

In Vitro and In Vivo Evaluation of Nitroxoline as an Effective Antimicrobial Alternative to Poultry Production.

Yuqing Zhou, Maria M Trush, Lewis Ibbotson, Laura Espina, Aditya Kumar Lankapalli, Alistair J M Farley, Huangwei Song, Congming Wu, Xingyuan Cao, Xi Xia and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yuqing ZhouDepartment of Biology and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.ORCID 0009-0003-3613-4027
Maria M TrushDepartment of Biology and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.ORCID 0000-0001-5462-7026
Lewis IbbotsonDepartment of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford,12 Mansfield Road, Oxford OX1 3TA, UK.ORCID 0000-0003-1078-3371
Laura EspinaFundación Agencia Aragonesa para la Investigación y el Desarrollo (ARAID), Avenida Ranillas 1D, 50018 Zaragoza, Spain.ORCID 0000-0002-3170-9755
Aditya Kumar LankapalliDepartment of Biology and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
Alistair J M FarleyDepartment of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford,12 Mansfield Road, Oxford OX1 3TA, UK.
Huangwei SongCollege of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China.
Congming WuCollege of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China.
Xingyuan CaoCollege of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China.ORCID 0000-0003-2063-6260
Xi XiaCollege of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China.
Charlotte J Gray-HammertonDepartment of Biology and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.ORCID 0009-0006-2183-6116
Alice MooreyDepartment of Biology and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
Amelie DelaitreDepartment of Biology and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
George SiegwartDepartment of Biology and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
Shaolin WangCollege of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China.
Yang WangCollege of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China.
Jianzhong ShenCollege of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China.
Christopher J SchofieldDepartment of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford,12 Mansfield Road, Oxford OX1 3TA, UK.ORCID 0000-0002-0290-6565
Timothy R WalshDepartment of Biology and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.

Funding

Ineos Oxford Institute for Antimicrobial Research, University of Oxford, UK n/a
6 · The paper itself

Abstract

backgroundAntimicrobial resistance is a major global challenge that is exacerbated by extensive antibiotic use in livestock farming. Identifying effective alternatives to widely used human antibiotics in animal production is vital to safeguard vital human medicines and ensure sustainable food systems. Here we describe studies identifying nitroxoline (NTX) as a promising antimicrobial candidate for use in poultry production.

methodsThe antibacterial activity and resistance potential of NTX were assessed in vitro. In vivo studies in chickens evaluated tolerance, therapeutic efficacy in

resultsNTX exhibits potent broad-spectrum antibacterial activity in vitro and low levels of resistance. NTX is well-tolerated in chickens at 500 mg/kg in-feed for 7 days and substantially reduces liver bacterial loads at 100 mg/kg in

conclusionsThese results indicate that NTX is a viable alternative to important human antibiotics widely deployed in poultry production, offering a potential approach to minimise antimicrobial resistance whilst maintaining animal health and food biosafety.

Indexed as

antimicrobial alternativegastrointestinal microbiotain vitro antibacterial activityin vivo efficacynitroxolinepharmacokineticspoultry productionwithdrawal time

Identifiers

PMID41594099
PMCPMC12838059

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.