Evidence map›Paper›PMID 41593870›Full record

ArticleACS applied materials & interfaces2026

Synergistic Effects in Matrix-Embedded Alloy Nanoclusters: Advanced Type-I Photosensitizers for Theranostics.

Negar Hosseiniyan, Pietro Castronovo, Gregory Beaune, Eslam Abdelrady, Xi Chen, Artem Zhyvolozhnyi, Hamza Siddiqui, Jahan Farhana, Hua Jiang, Minna Makki and 7 more

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Negar HosseiniyanDepartment of Applied Physics, Aalto University, P.O. Box 15100, FI-00076 Espoo, Finland.
Pietro CastronovoDipartimento di Fisica e Chimica - Emilio Segrè, Università degli Studi di Palermo, Via Archirafi 36, 90123 Palermo, Italy.ORCID 0009-0007-8267-7582
Gregory BeauneDepartment of Applied Physics, Aalto University, P.O. Box 15100, FI-00076 Espoo, Finland.
Eslam AbdelradyLaboratory of Developmental Biology, Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine, Infotech Oulu, Kvantum Institute, Oulu University, Aapistie 5A, 90014 Oulu, Finland.
Xi ChenDepartment of Applied Physics, Aalto University, P.O. Box 15100, FI-00076 Espoo, Finland.ORCID 0000-0001-6149-2270
Artem ZhyvolozhnyiLaboratory of Developmental Biology, Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine, Infotech Oulu, Kvantum Institute, Oulu University, Aapistie 5A, 90014 Oulu, Finland.
Hamza SiddiquiLaboratory of Developmental Biology, Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine, Infotech Oulu, Kvantum Institute, Oulu University, Aapistie 5A, 90014 Oulu, Finland.
Jahan FarhanaiCell Group, Research and Development, Finnish Red Cross Blood Service, Haartmaninkatu 8, FIN-00290 Helsinki, Finland.
Hua JiangDepartment of Applied Physics, Aalto University, P.O. Box 15100, FI-00076 Espoo, Finland.
Minna MakkiDepartment of Applied Physics, Aalto University, P.O. Box 15100, FI-00076 Espoo, Finland.
Marco CannasDipartimento di Fisica e Chimica - Emilio Segrè, Università degli Studi di Palermo, Via Archirafi 36, 90123 Palermo, Italy.ORCID 0000-0001-8236-5043
Alice SciortinoDipartimento di Fisica e Chimica - Emilio Segrè, Università degli Studi di Palermo, Via Archirafi 36, 90123 Palermo, Italy.ORCID 0000-0001-8361-3002
Ilya SkovorodkinLaboratory of Developmental Biology, Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine, Infotech Oulu, Kvantum Institute, Oulu University, Aapistie 5A, 90014 Oulu, Finland.
Anatoliy SamoylenkoLaboratory of Developmental Biology, Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine, Infotech Oulu, Kvantum Institute, Oulu University, Aapistie 5A, 90014 Oulu, Finland.ORCID 0000-0002-0240-897X
Seppo J VainioLaboratory of Developmental Biology, Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine, Infotech Oulu, Kvantum Institute, Oulu University, Aapistie 5A, 90014 Oulu, Finland.
Fabrizio MessinaDipartimento di Fisica e Chimica - Emilio Segrè, Università degli Studi di Palermo, Via Archirafi 36, 90123 Palermo, Italy.ORCID 0000-0002-2130-0120
Sourov ChandraDepartment of Applied Physics, Aalto University, P.O. Box 15100, FI-00076 Espoo, Finland.ORCID 0000-0003-0129-4242

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A combination of biomedical imaging and photodynamic therapy (PDT) in a single nanomaterial would be a breakthrough in nanomedicine. However, devising a single photosensitizer capable of efficient PDT without requiring an external oxygen source under typically hypoxic tumor conditions, combined with high photostability, biocompatibility, and renal clearance, remains a challenge. Atomically precise ultrasmall (<2 nm) gold nanoclusters (AuNCs) are emerging as potential multifunctional biomedicines, encompassing imaging, diagnosis, and therapy in a single nanoplatform. Herein, we report bioderived cellulose nanocrystal-supported gold nanoclusters (CNC-AuNCs) with selective mono or multiheteroatom (Ag, Pd, and Pt) substitution at the core of the nanoclusters. The replacement of one or more gold atoms significantly modulates their emission wavelengths, photoluminescence quantum yields, as well as excited-state relaxation kinetics. These materials can easily penetrate the cells, accumulating in the cytoplasm and emitting bright luminescence. While the nanocomposites are highly biocompatible, they can produce reactive oxygen species (ROS) through the formation of free radicals (O

Indexed as

AlloysMetal NanoparticlesPhotosensitizing AgentsTheranostic NanomedicineCelluloseGoldHumansPhotochemotherapyReactive Oxygen SpeciesAlloysCelluloseGoldPhotosensitizing AgentsReactive Oxygen Speciescellulose nanocrystalsgold nanoclustersphotosensitizerROStheranostics

Identifiers

PMID41593870
PMCPMC12903107

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.