ArticleKnee surgery & related research2026
Quadriceps muscle force magnitude and control in the knee scheduled for arthroplasty versus the contralateral knee: A cross-sectional study in patients with end-stage osteoarthritis.
Article in Knee surgery & related research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundKnee osteoarthritis (KOA) is a leading cause of musculoskeletal disability. Beyond the well-established impairment of reduced strength, deficits in force control (steadiness and complexity) may also influence functional performance. This cross-sectional study investigated quadriceps strength, force steadiness and complexity in patients with KOA and their associations with functional performance.
methodsA total of 48 patients scheduled for unilateral knee arthroplasty performed maximal voluntary isometric contraction in both limbs. A 2-s window from the trial containing the peak torque was used to compute quadriceps strength (average torque, AT), force steadiness (coefficient of variation, CV), and force complexity (sample entropy, SE; detrended fluctuation analysis alpha exponent). Functional performance was assessed via sitting-to-standing, single-leg stance, Timed Up and Go, and 30-s sit-to-stand tests. Comparisons between involved and contralateral limbs used analysis of variance (ANOVA) models, accounting for prior surgery in contralateral knees. Linear regression analyzed associations between functional performance and the lateral symmetry index (LSI) of AT and SE.
resultsResults showed significant differences between limbs for AT (P < 0.001, η
conclusionsKOA is associated with between-limb asymmetries in quadriceps strength and force complexity, with the involved knee exhibiting deleterious alterations. Nonetheless, force complexity was not correlated with functional performance.
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