ArticleParasites & vectors2026
Investigating genetic differentiation between brackish and fresh water collections of the arboviral vector Aedes aegypti.
Article in Parasites & vectors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Introgression Shapes Genetic Variation Associated With Humid Environments in Aedes aegypti Mosquitoes From Saudi Arabia.Molecular ecology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundAedes aegypti is typically regarded as a freshwater mosquito; however, recent studies have documented its development in brackish water habitats in coastal regions, including Sri Lanka's Jaffna Peninsula. Compared with freshwater populations, brackish water samples in Jaffna display enhanced salt tolerance throughout larval-to-adult development, along with differences in gene expression, cuticle morphology and composition, and insecticide susceptibility.
methodsTo explore the genetic basis of these differences, we performed a comparative genomic analysis using 5135 genome-wide single nucleotide polymorphisms (SNPs) from Ae. aegypti inhabiting freshwater and brackish water sites in the Jaffna Peninsula. Genetic diversity, population structure, and demographic parameters were evaluated using publicly available software. Candidate genomic regions potentially involved in salinity tolerance were identified through tests for environmental associations and genetic outlier detection.
resultsAfter performing genotype quality control and first-degree relative removal on the initial 121 mosquitoes genotyped, the final dataset comprised 13 freshwater and 21 brackish water individuals. Ae. aegypti populations from the Jaffna Peninsula showed limited evidence of genetic structuring by collection site, with a subtle pattern associated with larval water salinity (distance-based redundancy analysis [dbRDA] P = 0.002, adjusted R
conclusionsWe found subtle genetic differentiation between freshwater and brackish-water Ae. aegypti populations from the Jaffna Peninsula, suggesting that brackish-water populations may experience distinct evolutionary pressures potentially linked to adaptation to saline environments. Analyses point to fatty acid metabolism as one of the biological processes that could contribute to salinity tolerance in Ae. aegypti, possibly influencing cuticle modifications as a physiological response. Additional studies incorporating more collection sites and larger sample sizes for each salinity group are needed to further elucidate the mechanisms driving this differentiation. The ability of Ae. aegypti to adapt to brackish water substantially expands the range of potential larval sites it can occupy, particularly in coastal areas, and emphasizes the need to adjust vector control strategies accordingly.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.