Evidence map›Paper›PMID 41593783›Full record

ArticleBMC sports science, medicine & rehabilitation2026

Adding blood flow restriction to isokinetic resistance training provides no additional benefit for strength, but may improve local muscular endurance: a randomized controlled trial.

Hüseyin Günaydın, Bihter Akınoğlu, Aydan Örsçelik, Erdoğan Asar, Gökhan Büyüklüoğlu, Tuğba Kocahan

Registry-linked trialAbstract read
In one paragraph

Article in BMC sports science, medicine & rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06678009 (The Effect of 8-week Isokinetic Training Combined with Blood Flow Restriction on Muscle Strength and Endurance in Runners), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06678009 nacompletednot on this map

The Effect of 8-week Isokinetic Training Combined with Blood Flow Restriction on Muscle Strength and Endurance in Runners

TypeinterventionalSponsorBihter AslanyurekRan2022 to 2024Enrolled42ConditionsBlood Flow RestrictionArmsthe isokinetic training group with blood flow restriction, the isokinetic training group without blood flow restriction
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hüseyin GünaydınDepartment of Sports Medicine, Gülhane Faculty of Medicine, University of Health Sciences, Ankara, Türkiye.
Bihter AkınoğluDepartment of Physiotherapy and Rehabilitation, Faculty of Health Sciences, University of Ankara Yildirim Beyazit, Ankara, Türkiye.
Aydan ÖrsçelikDepartment of Sports Medicine, Gülhane Faculty of Medicine, University of Health Sciences, Ankara, Türkiye.
Erdoğan AsarDepartment of Medical Informatics, Gülhane Faculty of Medicine, University of Health Sciences, Ankara, Türkiye.
Gökhan BüyüklüoğluDepartment of Sports Medicine, Gülhane Faculty of Medicine, University of Health Sciences, Ankara, Türkiye.
Tuğba KocahanDepartment of Sports Medicine, Gülhane Faculty of Medicine, University of Health Sciences, Ankara, Türkiye. kocahantu@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study investigated the effects of adding blood flow restriction (BFR) to high-load isokinetic resistance training on muscle strength and local muscular endurance.

methodsForty-two middle- and long-distance runners were randomly assigned to an isokinetic training group with BFR (BFR group; n = 21) or an isokinetic training group without BFR (non-BFR group; n = 21). The training protocol consisted of concentric knee flexion and extension exercises performed at angular velocities of 60°/s (3 sets of 10 maximal repetitions) and 180°/s (3 sets of 30 maximal repetitions), twice weekly for 8 weeks. BFR was applied at 80% of arterial occlusion pressure (AOP) in the BFR group. Muscle strength (peak torque [PT]) and local muscular endurance (fatigue index [FI]) were evaluated before and after the intervention.

resultsBoth groups demonstrated significant increases in muscle strength for both knee flexors and extensors at angular velocities of 60°/s and 180°/s. However, no significant between-group differences were observed for strength gains (p > 0.05 for all comparisons). Regarding local muscular endurance, the magnitude of improvement in FI was significantly greater in the BFR group compared to the non-BFR group for both flexors (p = 0.003, η²= 0.102) and extensors (p = 0.005, η²= 0.091).

conclusionsThis study demonstrates that adding BFR to high-load isokinetic resistance training does not enhance muscle strength beyond high-load isokinetic resistance training but significantly improves local muscular endurance, as evidenced by greater reductions in FI in the BFR group. These findings suggest that BFR may be a valuable tool for optimizing endurance-specific adaptations in athletic populations requiring sustained performance. Future research should explore optimal BFR protocols for endurance-focused training across diverse athletic disciplines.

trial registrationRegistration date: 04/11/2024, ClinicalTrials: NCT06678009.

Indexed as

Blood flow restrictionFatigue indexIsokinetic trainingLocal muscular enduranceResistance exercise

Identifiers

PMID41593783
PMCPMC12924596

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.