ArticleJournal of cardiothoracic surgery2026
Clinicopathological and immunophenotypic characteristics of minute pulmonary meningothelial-like nodules comorbid with lung adenocarcinoma.
Article in Journal of cardiothoracic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThe aim of this study was to delineate the clinicopathological features and diagnostic immunophenotype of minute pulmonary meningothelial-like nodules (MPMNs), particularly with lung adenocarcinoma.
methodsA retrospective evaluation was performed on nine cases of MPMNs diagnosed between 2017 and 2021. Data included imaging findings, histomorphological characteristics, and immunohistochemical (IHC) profiles. A literature review was conducted to examine diagnostic and differential diagnostic considerations.
resultsOf the 9 patients, 6 (66.7%) were female, yielding a male-to-female ratio of 1:2. The mean age was 65.6 ± 9.0 years. Pulmonary adenocarcinoma was concurrently identified in eight cases (88.9%). Common comorbidities included hypertension (66.7%), cerebral infarction (33.3%), and diabetes mellitus (22.2%). Among those with hypertension, 83.3% (5/6) had received treatment with dihydropyridines. Lesions were more frequently located in the right lung (55.6%), with ground-glass nodules observed in 55.6% of cases on computed tomography. All cases were confirmed by histopathological analysis following thoracoscopic segmentectomy or lobectomy. Histologically, the nodules measured 0.10–0.50 cm and were well-circumscribed, consisting of short spindle-shaped cells arranged in whorled or nested patterns. IHC indicated consistent positivity for vimentin and epithelial membrane antigen in all cases (100%), partial positivity for CD56 (66.7%), and negativity for SMA and cytokeratin.
conclusionsMPMNs represent benign lesions, most commonly identified in older adult females and frequently associated with pulmonary adenocarcinoma. Imaging findings are non-specific, and definitive diagnosis relies on histopathological and IHC features, notably vimentin+/EMA+/CK − expression profiles.
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