Evidence map›Paper›PMID 41593737›Full record

ArticleTrials2026

High-intensity training vs. low-intensity training for patients with anxiety: a randomised controlled trial.

Martin Bystad, Sveinung Rydland, Christian Bugge, Sissel Høgmo, Birgit Brøndbo, Renate Jacobsen, Lorena García-Fernández, Roberto Rodríguez-Jiménez, Verónica Romero-Ferreiro, Rolf Wynn

Registry-linked trialAbstract readClinical Trial ProtocolComparative Study
In one paragraph

Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06881758 (High Intensity Training for Patients with Anxiety), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06881758 naenrolling by invitationnot on this map

High Intensity Training for Patients with Anxiety

TypeinterventionalSponsorUniversity Hospital of North NorwayRan2025 to 2027Enrolled26ConditionsAnxiety, Depression Anxiety Disorder, Blood Pressure Check (Hypertension Screening)ArmsExercise
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Martin BystadDivision of Substance Use and Mental Health, University Hospital of North Norway, Tromsø, Norway.
Sveinung RydlandDivision of Substance Use and Mental Health, University Hospital of North Norway, Tromsø, Norway.
Christian BuggeDivision of Substance Use and Mental Health, University Hospital of North Norway, Tromsø, Norway.
Sissel HøgmoDivision of Substance Use and Mental Health, University Hospital of North Norway, Tromsø, Norway.
Birgit BrøndboDivision of Substance Use and Mental Health, University Hospital of North Norway, Tromsø, Norway.
Renate JacobsenDivision of Substance Use and Mental Health, University Hospital of North Norway, Tromsø, Norway.
Lorena García-FernándezCIBERSAM-ISCIII (Biomedical Research Networking Centre in Mental Health), Madrid, Spain.
Roberto Rodríguez-JiménezCIBERSAM-ISCIII (Biomedical Research Networking Centre in Mental Health), Madrid, Spain.
Verónica Romero-FerreiroCIBERSAM-ISCIII (Biomedical Research Networking Centre in Mental Health), Madrid, Spain.
Rolf WynnDivision of Substance Use and Mental Health, University Hospital of North Norway, Tromsø, Norway. rolf.wynn@uit.no.ORCID http://orcid.org/0000-0002-2254-3343

Funding

Helse Nord RHF Strategisk-HN23-23
6 · The paper itself

Abstract

backgroundThis protocol was developed to describe the design of a randomised controlled trial that will examine the clinical efficacy of a 4-week comparison of high-intensity vs. low-intensity physical training for people suffering from anxiety. The hypothesis is that the high-intensity group will have greater benefit in terms of reduced anxiety symptoms, improved physical health (blood pressure) and better adherence.

methodsThirty adults aged 18 to 70 years diagnosed with an anxiety disorder will be recruited for this study. Participants will be randomised into an intervention group (high-intensity training) and a control group (low-intensity training). Randomisation will be performed using counterbalanced block randomisation in a 1:1 ratio, stratified by sex. Both groups will perform 4 weeks of twice-weekly training supervised by an exercise physiologist. The primary outcome will be the total score on the Hospital Anxiety and Depression Scale (HADS) and the total score on the Beck Anxiety Inventory (BAI). The secondary outcomes include blood-pressure changes and adherence. Evaluations will be performed at baseline and following 4 weeks of the interventions, and 6 months after the termination of the intervention period (secondary endpoint). DISCUSSION: By investigating the clinical efficacy of a 4-week training intervention, we hope to provide applicable and generalisable knowledge about the efficacy of physical training for people suffering from anxiety disorders.

trial registrationClinical Trials NCT06881758 . Registered on 17 March 2025.

Indexed as

AnxietyAnxiety DisordersExercise TherapyAdolescentAdultAgedBlood PressureFemaleHumansMaleMiddle AgedPatient CompliancePsychiatric Status Rating ScalesRandomized Controlled Trials as TopicResearch DesignTime FactorsAnxietyHigh-intensityLow-intensityPhysical trainingRCT

Identifiers

PMID41593737
PMCPMC12917961

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.