ArticleJournal of orthopaedic surgery and research2026
Elevated miR-409-5p may promote the progression of osteoarthritis by targeting DLST as a potential biomarker function of miR-409-5p in osteoarthritis.
Article in Journal of orthopaedic surgery and research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundOsteoarthritis (OA) significantly impairs the quality of life of middle-aged and elderly individuals. MicroRNAs (miRNAs) are known to play key regulatory roles in OA progression.
aimsTo investigate the potential role mechanisms of miR-409-5p in OA.
methodsThis study enrolled 93 OA patients and 75 non-OA controls. The expression levels of miR-409-5p, DLST, and OA-related markers were measured using RT-qPCR or Western Blot. The targeting relationship between miR-409-5p and DLST was verified by dual luciferase reporter assays. Cell viability was assessed with the CCK-8 assay, and inflammatory cytokine concentrations were measured via ELISA.
resultsSerum miR-409-5p expression was higher in OA patients than in controls and showed good diagnostic value for OA. Inhibiting miR-409-5p suppressed IL-1β-induced viability in CHON-001 cells, promoted aggrecan expression, suppressed MMP13 expression, and reduced secretion of IL-6 and IL-8. MiR-409-5p directly targeted DLST, and their expression levels were negatively correlated. Knockdown of DLST abolished the beneficial effects of miR-409-5p inhibition on cell viability, extracellular matrix degradation, and inflammatory responses.
conclusionsMiR-409-5p was highly expressed in OA and may promote disease progression by targeting DLST.
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