Evidence map›Paper›PMID 41593613›Full record

ArticleBMC pulmonary medicine2026

Bronchoalveolar lavage cell differential count is associated with survival and radiological UIP pattern in familial pulmonary fibrosis.

Hanna Jaula, Johanna Leppänen, Lauri Mattila, Lauri Ahvenjärvi, Eerika Nurkkala, Henri Lampela, Elisa Lappi-Blanco, Hannu Vähänikkilä, Terttu Harju, Riitta Kaarteenaho

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Article in BMC pulmonary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hanna JaulaResearch Unit of Biomedicine and Internal Medicine, University of Oulu, Oulun yliopisto, P.O. Box 8000, Oulu, FI-90014, Finland. hanna.jaula@oulu.fi.
Johanna LeppänenResearch Unit of Biomedicine and Internal Medicine, University of Oulu, Oulun yliopisto, P.O. Box 8000, Oulu, FI-90014, Finland.
Lauri MattilaDepartment of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland.
Lauri AhvenjärviDepartment of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland.
Eerika NurkkalaClinical Microbiology, NordLab, Oulu, Finland.
Henri LampelaResearch Unit of Biomedicine and Internal Medicine, University of Oulu, Oulun yliopisto, P.O. Box 8000, Oulu, FI-90014, Finland.
Elisa Lappi-BlancoDepartment of Pathology, Oulu University Hospital, Oulu, Finland.
Hannu VähänikkiläNorthern Finland Birth Cohorts, Arctic Biobank, Infrastructure for Population studies, Faculty of Medicine, University of Oulu, Oulu, Finland.
Terttu HarjuResearch Unit of Biomedicine and Internal Medicine, University of Oulu, Oulun yliopisto, P.O. Box 8000, Oulu, FI-90014, Finland.
Riitta KaarteenahoResearch Unit of Biomedicine and Internal Medicine, University of Oulu, Oulun yliopisto, P.O. Box 8000, Oulu, FI-90014, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBronchoalveolar lavage fluid (BAL) cell differential count analysis is a common diagnostic tool in interstitial lung diseases (ILD), but studies of the BAL cell profile in familial pulmonary fibrosis (FPF) are sparse. In this retrospective cohort study, we aimed to determine BAL cell profile in patients with FPF and to compare findings to those with idiopathic pulmonary fibrosis (IPF) or asbestosis. We also investigated BAL cell profile according to clinical features, radiological usual interstitial pneumonia (UIP) patterns, survival and additionally in the subgroups of the patients with pathogenic gene variants and histological investigations.

methodsData were collected from medical records between 1 January 2000 and 30 September 2024. The inclusion criterion was pulmonary fibrosis (PF) (ICD 10-code J84.X), with at least one self-reported relative with PF and BAL data available. High-resolution computer tomography (HRCT) scans and histology were re-evaluated.

resultsThe BAL results of 49 FPF patients were compared with 72 IPF and 90 asbestosis cases. Differences in BAL cell profile were revealed between groups of FPF, IPF, and asbestosis. Furthermore, we found differences in BAL cell profile between smoking habits and radiological UIP patterns. The BAL results of the patients with pathogenic gene variants were variable. Moreover, BAL eosinophils associated with survival in FPF and familial IPF.

conclusionsAs a novel finding, a high proportion of BAL eosinophils is associated with shortened survival of patients with FPF, thus emphasising the need to further investigate the role of eosinophils in the pathogenesis of FPF.

Indexed as

AsbestosisBronchoalveolar Lavage FluidIdiopathic Pulmonary FibrosisAgedCell CountEosinophilsFemaleHumansMaleMiddle AgedRetrospective StudiesTomography, X-Ray ComputedBronchoalveolar lavageFamilial idiopathic pulmonary fibrosisFamilial pulmonary fibrosisHistopathologyInterstitial lung diseaseRadiologySurvival

Identifiers

PMID41593613
PMCPMC12918469

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.