ArticleBMC psychiatry2026
The mediating role of anxiety in the association between childhood trauma and suicidal ideation in depression.
Article in BMC psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Suicidality-Related Emergency Department Visits Among US Children and Adolescents, 2016-2022.JAACAP open · 2026Article
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11 authors.
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Abstract
purposeSuicidal ideation (SI) is a major public health concern, especially in patients with major depressive disorder (MDD). Although various psychosocial factors are associated with SI, the complex interrelationships among childhood trauma (CT), anxiety symptoms, depressive symptoms, and anhedonia remain inadequately understood. This study examined these relationships and their associations with SI.
methodsThis cross-sectional study included 782 patients with MDD consecutively recruited from the inpatient and outpatient clinics of the Department of Psychiatry at Renmin Hospital of Wuhan University between April 2019 and August 2023. Assessments were conducted using validated Chinese versions of the Childhood Trauma Questionnaire-Short Form, Hamilton Anxiety Rating Scale, Snaith-Hamilton Pleasure Scale, Hamilton Depression Scale, Patient Health Questionnaire-15, and Life Event Scale. Statistical analyses comprised chi-square tests, t-tests, binary logistic regression, Pearson’s correlation analysis, and structural equation modeling (SEM).
resultsAnxiety symptoms were present in 425 patients (54.35%), of whom 84.24% reported SI. Patients with anxiety symptoms demonstrated significant differences in emotional neglect, physical neglect, emotional abuse, physical abuse, anhedonia, depressive symptoms, somatic symptoms, negative life events, and SI compared to those without anxiety. SEM analysis indicated direct associations of CT, depressive symptoms, and anhedonia with SI. Additionally, anxiety symptoms showed indirect associations with SI, linked through their connections with CT, anhedonia, and depressive symptoms.
conclusionsThe findings highlight the clinical relevance of assessing CT and the interrelated symptom cluster of anxiety, anhedonia, and depression in MDD patients with SI. This supports the consideration of integrated treatment strategies that concurrently address these domains. CLINICAL TRIAL NUMBER: Not applicable.
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