Evidence map›Paper›PMID 41593496›Full record

Trial reportBMC anesthesiology2026

Effect of low-dose propofol infusion with sevoflurane versus propofol-only total intravenous anesthesia on postoperative nausea and vomiting in high-risk patients: a single-blind randomized controlled clinical trial.

Wyatt L Keck, Elen Deng, Wai-Man Liu, Revati Kanekar, Vladimir Lomivorotov, Sonal Sharma

Erratum issued Registry-linked trialAbstract readClinical Trial, Phase IIComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05759481 (Prevention of Post-Operative Nausea and Vomiting With Propofol Infusion), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05759481 phase2completednot on this map

Prevention of Post-Operative Nausea and Vomiting With Propofol Infusion

TypeinterventionalSponsorMilton S. Hershey Medical CenterRan2024 to 2025Enrolled65ConditionsPost-operative Nausea and VomitingArmsHybrid anesthesia (propofol + sevoflurane), Propofol only TIVA
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Wyatt L KeckDepartment of Anesthesiology and Perioperative Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.
Elen DengPenn State College of Medicine, 700 HMC Cres Rd, Hershey, PA, 17033, USA. edeng@pennstatehealth.psu.edu.
Wai-Man LiuResearch School of Finance, Actuarial Studies and Statistics, Australian National University, Canberra, Australia.
Revati KanekarDepartment of Anesthesiology and Perioperative Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.
Vladimir LomivorotovDepartment of Anesthesiology and Perioperative Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.
Sonal SharmaDepartment of Anesthesiology and Perioperative Medicine, University of Pittsburgh Medical Center Presbytarian Hospital, Pittsburgh, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative nausea and vomiting (PONV) is a common complication following general anesthesia, and may lead to delayed recovery and prolonged hospital length of stay. While propofol has been shown to reduce PONV risk, volatile anesthetics like sevoflurane are associated with a higher incidence.

objectiveThis study compares the incidence of PONV within 24 h after surgery between propofol based total intravenous anesthesia (TIVA) and a hybrid technique using low-dose propofol infusion with sevoflurane in patients with a prior history of PONV and/or motion sickness.

designA prospective, single-blind, randomized controlled clinical trial was conducted in adult patients undergoing laparoscopic surgery at Penn State Health Milton S. Hershey Medical Center from February 2024 to March 2025.

interventionPatients received either TIVA or a low-dose propofol infusion combined with sevoflurane. The primary outcome was the cumulative incidence of PONV within 24 hours postoperatively. Secondary outcomes included PONV in the post-anesthesia care unit (PACU) and use of rescue antiemetics.

resultsA total of 65 patients were included, (32 hybrid anesthesia, 33 propofol TIVA). PONV occurred in 28% of patients receiving hybrid anesthesia compared to 21% receiving TIVA (p = 0.44). At 24 h, PONV was reported by 59% in the hybrid group and 42% in the TIVA group (p = 0.17).

conclusionLow-dose propofol infusion combined with sevoflurane resulted in PONV rates that were not statistically different from propofol-based TIVA. Trial registration: NCT05759481, registered on 02/22/2023.

Indexed as

Anesthesia, IntravenousAnesthetics, IntravenousPostoperative Nausea and VomitingPropofolSevofluraneAdultAnesthetics, InhalationFemaleHumansInfusions, IntravenousMaleMiddle AgedProspective StudiesSingle-Blind MethodAnesthetics, InhalationAnesthetics, IntravenousPropofolSevofluraneMotion sicknessNauseaPostoperativePropofolSevofluraneVomiting

Identifiers

PMID41593496
PMCPMC12924609

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.