Evidence map›Paper›PMID 41593398›Full record

ArticleCurrent microbiology2026

Preparation and Serological Evaluation of an Inactivated Trivalent Oil Emulsion Vaccine for Avian Fowl Adenovirus (FAdV) Containing - 8a, 8b, and 11 Serotypes.

Ferial Eliwa Ibrahim, Mohamed Nasr Fathi Shaheen, Hasnaa Maged, Mahmoud Ibrahim, Yakout Abdelfatah El-Senosi, Samy Ali Hussein Aziza, Afaf Desoky Abdel Magid, Ahmed El-Sanousi

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Article in Current microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ferial Eliwa IbrahimVaccine Valley, Egyptian Company for Biological & Pharmaceutical Industries, 101 extension of the sixth industrial Zone-6th of October City, Giza, Egypt.
Mohamed Nasr Fathi ShaheenVaccine Valley, Egyptian Company for Biological & Pharmaceutical Industries, 101 extension of the sixth industrial Zone-6th of October City, Giza, Egypt. m_nrc2007@yahoo.com.
Hasnaa MagedVaccine Valley, Egyptian Company for Biological & Pharmaceutical Industries, 101 extension of the sixth industrial Zone-6th of October City, Giza, Egypt.
Mahmoud IbrahimVaccine Valley, Egyptian Company for Biological & Pharmaceutical Industries, 101 extension of the sixth industrial Zone-6th of October City, Giza, Egypt.
Yakout Abdelfatah El-SenosiDepartment of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Benha University, Benha, Egypt.
Samy Ali Hussein AzizaDepartment of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Benha University, Benha, Egypt.
Afaf Desoky Abdel MagidDepartment of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Benha University, Benha, Egypt.
Ahmed El-SanousiVaccine Valley, Egyptian Company for Biological & Pharmaceutical Industries, 101 extension of the sixth industrial Zone-6th of October City, Giza, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inclusion body hepatitis (IBH), caused by fowl adenovirus (FAdV) species D and E, results in significant economic losses for the poultry industry. This study aimed to evaluate the immunogenicity of an inactivated trivalent FAdV vaccine in SPF chickens, specifically assessing the effects of antigen payload, thimerosal addition, and booster immunization on antibody titers. Results demonstrated a clear dose-response, with higher antigen payloads eliciting a more prolonged immune response compared to the lowest dose. Thimerosal was confirmed to be a safe preservative, showing no negative impact on antibody development. Furthermore, a booster immunization significantly increased antibody levels, but this effect was observed only in the group receiving the high-payload vaccine, with peak titers at weeks 2 and 3 post-vaccination. These findings indicate that a high-dose trivalent inactivated FAdV vaccine, administered with a booster, is highly immunogenic and represents a promising strategy for the effective prevention and control of IBH.

Indexed as

Adenoviridae InfectionsAviadenovirusPoultry DiseasesViral VaccinesAnimalsAntibodies, ViralChickensEmulsionsSerogroupVaccinationVaccines, InactivatedAntibodies, ViralEmulsionsVaccines, InactivatedViral VaccinesChickenFAdVIBHImmunizationVaccine

Identifiers

PMID41593398

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.