Evidence map›Paper›PMID 41593371›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026

Predicting recovery in Bell's palsy: the impact of early rehabilitation and prognostic indicators.

Daniela Lucidi, Virginia Dallari, Federico Spagnolo, Giannicola Iannella, Federica Nizzoli, Elena Reggiani, Ignacio Javier Fernandez

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Daniela LucidiDepartment of Otolaryngology Head and Neck Surgery, Santa Maria Delle Croci Hospital, AUSL Della Romagna, Ravenna, Italy.
Virginia DallariDepartment of Otolaryngology Head and Neck Surgery, Santa Maria Delle Croci Hospital, AUSL Della Romagna, Ravenna, Italy. virginia.dallari@gmail.com.ORCID http://orcid.org/0000-0001-9260-1003
Federico SpagnoloDepartment of Otolaryngology, Sassuolo Hospital, AUSL Modena, Sassuolo, Italy.
Giannicola IannellaDepartment of 'Organi di Senso', University "Sapienza", Rome, 00185, Italy.
Federica NizzoliDepartment of Otolaryngology, University Hospital of Modena, Modena, Italy.
Elena ReggianiDepartment of Otolaryngology, University Hospital of Modena, Modena, Italy.
Ignacio Javier FernandezDepartment of Otolaryngology Head and Neck Surgery, Santa Maria Delle Croci Hospital, AUSL Della Romagna, Ravenna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate functional outcomes and prognostic factors in Bell's palsy (BP) patients treated with medical therapy and facial neuromuscular retraining (fNMR), with a focus on the timing of rehabilitation.

methodsNinety-four patients with FP treated at our center were retrospectively analyzed. Patients were stratified by time to rehabilitation (TTR): Early Rehabilitation (≤ 60 days), who accessed our unit directly, and Late Rehabilitation (> 60 days), who had first received other treatments or rehabilitation not including fNMR elsewhere. Outcomes included House-Brackmann (HB) grade, Sunnybrook score, synkinesis, and time to recovery onset (TTRO). Complete recovery was defined as HB I at 12 months.

resultsAt 12 months, 60 patients (63.8%) achieved complete recovery, while 34 (36.2%) did not. Median TTR was 23 days [IQR 16-68], and median TTRO was 48 days [30-113]. Early Rehabilitation was associated with significantly better outcomes at 6 and 12 months, with higher Sunnybrook scores and lower HB grades (all p < 0.001), and with faster TTRO. In univariable analyses, cardiovascular and metabolic comorbidities were associated with poorer recovery. Longer TTR, delayed TTRO, higher baseline HB, lower baseline Sunnybrook, synkinesis, and previous rehabilitation were predictors of worse outcomes. At multivariable logistic regression, TTRO emerged as the only independent predictor of complete recovery (p = 0.017).

conclusionsEarly initiation of standardized fNMR was associated with more favorable functional recovery, while delayed rehabilitation and systemic comorbidities predicted worse outcomes. Recovery beyond 12 months was exceptional, confirming the first year as the critical window for meaningful nerve regeneration.

Indexed as

Bell PalsyRecovery of FunctionAdultAgedFemaleGlucocorticoidsHumansMaleMiddle AgedPrognosisRetrospective StudiesTime FactorsTreatment OutcomeGlucocorticoidsBell’s palsyComorbiditiesFacial nerveGlucocorticoidsNeuromuscular retrainingRehabilitation

Identifiers

PMID41593371
PMCPMC13002638

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.