Evidence map›Paper›PMID 41593343›Full record

ArticleScientific reports2026

Characteristics of motor polyneuropathy in Fabry disease: a case-control study.

Magdalena Koszewicz, Edyta Dziadkowiak, Mariusz Szydlo, Malgorzata Wieczorek, Krzysztof Slotwinski, Hanna Augustyniak-Bartosik

Abstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Magdalena KoszewiczClinical Neurophysiology Laboratory, University Centre of Neurology and Neurosurgery, Faculty of Medicine, Wroclaw Medical University, Borowska 213, Wroclaw, 50-556, Poland. magdalena.koszewicz@umw.edu.pl.
Edyta DziadkowiakClinical Department of Neurology, University Centre of Neurology and Neurosurgery, Faculty of Medicine, Wroclaw Medical University, Borowska 213, Wroclaw, 50-556, Poland.
Mariusz SzydloClinical Department of Neurology, University Centre of Neurology and Neurosurgery, Faculty of Medicine, Wroclaw Medical University, Borowska 213, Wroclaw, 50-556, Poland.
Malgorzata WieczorekFaculty of Earth Sciences and Environmental Management, University of Wroclaw, Uniwersytecki Square 1, Wroclaw, 50-137, Poland.
Krzysztof SlotwinskiClinical Neurophysiology Laboratory, University Centre of Neurology and Neurosurgery, Faculty of Medicine, Wroclaw Medical University, Borowska 213, Wroclaw, 50-556, Poland.
Hanna Augustyniak-BartosikDepartment of Non-procedural Clinical Sciences, Faculty of Medicine, Wroclaw University of Science and Technology, Grunwaldzki Square 11, Wroclaw, 51- 377, Poland.

Funding

Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu SUBZ.A520.25.008
6 · The paper itself

Abstract

In Fabry disease (FD) neuropathic pain is often the first symptom due to impairment of the small fibres of peripheral nerves. The problem of large fibre involvement in FD has not been described well. This prompted us to investigate electrophysiological changes in motor fibres with different conduction velocities in FD patients.The study group consisted of 20 patients with FD (8 women and 12 men); mean age was 40.65 ± 11.94 years, and a matched control group. Medical history, neurological examination, together with standard neurography and conduction velocity distribution (CVD) tests of the ulnar and peroneal nerves, were performed. Different comorbidities were more frequent in men. Statistically significant slowing of motor conduction velocity in both nerves and a significant reduction in the amplitude of the motor response in the peroneal nerve were found in FD patients. Conduction slowing in motor fibres in standard and CVD tests was more pronounced in men and in patients with chronic kidney disease (CKD). Damage to motor fibres occurs in more advanced stages of FD, with greater severity in patients with other comorbidities, mainly CKD. The demyelinating process is important for the development of FD polyneuropathy.

Indexed as

Fabry DiseaseMotor NeuronsPolyneuropathiesAdultCase-Control StudiesFemaleHumansMaleMiddle AgedNerve Conduction StudiesNeural ConductionPeroneal NerveUlnar NerveChronic kidney diseaseConduction velocity distribution testFabry diseaseGenderMotor polyneuropathy

Identifiers

PMID41593343
PMCPMC12905325

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Registered trials

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