Evidence map›Paper›PMID 41593328›Full record

ArticleCell research2026

The axon initial segment-associated microglia regulate neuronal activity and visual perception.

Yaping Wang, Qiushi Wang, Chen Gao, Shu He, Cheng Wei, Jia Song, Xinli Liu, Xiaoli Liu, Shi Feng, Wen Yao and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Yaping Wang *Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence; State Key Laboratory of Multi-organ Injury Prevention and Treatment; Key Laboratory of Mental Health of the Ministry of Education; Guangdong Province Key Laboratory of Psychiatric Disorders; Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases; Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders; Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Qiushi Wang *Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence; State Key Laboratory of Multi-organ Injury Prevention and Treatment; Key Laboratory of Mental Health of the Ministry of Education; Guangdong Province Key Laboratory of Psychiatric Disorders; Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases; Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders; Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Chen GaoGuangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence; State Key Laboratory of Multi-organ Injury Prevention and Treatment; Key Laboratory of Mental Health of the Ministry of Education; Guangdong Province Key Laboratory of Psychiatric Disorders; Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases; Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders; Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Shu HeGuangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence; State Key Laboratory of Multi-organ Injury Prevention and Treatment; Key Laboratory of Mental Health of the Ministry of Education; Guangdong Province Key Laboratory of Psychiatric Disorders; Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases; Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders; Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Cheng WeiGuangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence; State Key Laboratory of Multi-organ Injury Prevention and Treatment; Key Laboratory of Mental Health of the Ministry of Education; Guangdong Province Key Laboratory of Psychiatric Disorders; Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases; Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders; Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Jia SongGuangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence; State Key Laboratory of Multi-organ Injury Prevention and Treatment; Key Laboratory of Mental Health of the Ministry of Education; Guangdong Province Key Laboratory of Psychiatric Disorders; Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases; Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders; Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Xinli LiuDepartment of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Xiaoli LiuGuangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence; State Key Laboratory of Multi-organ Injury Prevention and Treatment; Key Laboratory of Mental Health of the Ministry of Education; Guangdong Province Key Laboratory of Psychiatric Disorders; Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases; Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders; Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Shi FengGuangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence; State Key Laboratory of Multi-organ Injury Prevention and Treatment; Key Laboratory of Mental Health of the Ministry of Education; Guangdong Province Key Laboratory of Psychiatric Disorders; Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases; Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders; Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Wen YaoGuangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence; State Key Laboratory of Multi-organ Injury Prevention and Treatment; Key Laboratory of Mental Health of the Ministry of Education; Guangdong Province Key Laboratory of Psychiatric Disorders; Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases; Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders; Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Wen WuDepartment of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.ORCID 0000-0002-5576-2999
Tian-Ming GaoGuangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence; State Key Laboratory of Multi-organ Injury Prevention and Treatment; Key Laboratory of Mental Health of the Ministry of Education; Guangdong Province Key Laboratory of Psychiatric Disorders; Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases; Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders; Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.ORCID 0000-0003-4594-9052
Siqiang RenGuangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence; State Key Laboratory of Multi-organ Injury Prevention and Treatment; Key Laboratory of Mental Health of the Ministry of Education; Guangdong Province Key Laboratory of Psychiatric Disorders; Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases; Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders; Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China. rensiqiang159@smu.edu.cn.ORCID 0000-0002-3244-4330

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As innate immune cells in the brain, microglia directly contact excitatory neurons and regulate their activities under various conditions; however, the mechanisms of direct microglia-neuron functional interactions remain largely unknown. Here, we identified one special population of neocortical microglia that specifically associate with the axon initial segments (AISs) of excitatory neurons, and could regulate their activities and contribute to visual perception. We found that brief depolarization of AIS-associated microglia, but not the AIS-non-associated microglia, significantly promoted the action potential firing of related excitatory neurons, which relied mechanistically on microglial K

Indexed as

Axon Initial SegmentMicrogliaNeuronsVisual PerceptionAction PotentialsAnimalsCalciumMaleMiceMice, Inbred C57BLPhotic StimulationPotassiumPotassium ChannelsCalciumPotassiumPotassium Channels

Identifiers

PMID41593328
PMCPMC13013605

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.