Evidence map›Paper›PMID 41593269›Full record

Observational studyScientific reports2026

Plasma fatty acid profiles and coronary artery disease burden assessed by coronary CT angiography: an observational study.

Pich Chhay, Dantong Zhu, Owen Tang, Michael P Gray, Stephen T Vernon, Belinda A Di Bartolo, Katharine A Kott, Stuart M Grieve, Robert A Gibson, Peter J Psaltis and 1 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Pich ChhayCardiovascular Discovery Group, Kolling Institute of Medical Research, Northern Sydney Local Health District, St Leonards, Sydney, NSW, 2065, Australia.
Dantong ZhuCardiovascular Discovery Group, Kolling Institute of Medical Research, Northern Sydney Local Health District, St Leonards, Sydney, NSW, 2065, Australia.
Owen TangCardiovascular Discovery Group, Kolling Institute of Medical Research, Northern Sydney Local Health District, St Leonards, Sydney, NSW, 2065, Australia.
Michael P GrayCardiovascular Discovery Group, Kolling Institute of Medical Research, Northern Sydney Local Health District, St Leonards, Sydney, NSW, 2065, Australia.
Stephen T VernonCardiovascular Discovery Group, Kolling Institute of Medical Research, Northern Sydney Local Health District, St Leonards, Sydney, NSW, 2065, Australia.
Belinda A Di BartoloCardiovascular Discovery Group, Kolling Institute of Medical Research, Northern Sydney Local Health District, St Leonards, Sydney, NSW, 2065, Australia.
Katharine A KottCardiovascular Discovery Group, Kolling Institute of Medical Research, Northern Sydney Local Health District, St Leonards, Sydney, NSW, 2065, Australia.
Stuart M GrieveImaging and Phenotyping Laboratory, Charles Perkins Centre, University of Sydney, Camperdown, Sydney, NSW, 2006, Australia.
Robert A GibsonChild Nutrition Research Centre, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia.
Peter J PsaltisVascular Research Centre, Lifelong Health, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia.
Gemma A FigtreeCardiovascular Discovery Group, Kolling Institute of Medical Research, Northern Sydney Local Health District, St Leonards, Sydney, NSW, 2065, Australia. gemma.figtree@sydney.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerotic coronary artery disease (CAD) remains a leading cause of death globally, and individual susceptibility is not fully explained by standard risk factors. The role of plasma fatty acid profiles in relation to imaging-defined CAD burden remains less well established. We performed a cross-sectional cohort analysis of 1,002 participants undergoing coronary computed tomographic angiography (CCTA), with blood samples collected immediately prior to contrast administration. Plasma fatty acids were quantified as a percentage of total plasma fatty acids and evaluated for associations with CAD burden, including coronary artery calcium score (CACS), CACS percentile, Gensini score, soft plaque score, and atrial fibrillation (AF). Associations were assessed using multivariate logistic regression, adjusting for age, sex, and cardiovascular risk factors. Higher plasma omega-6 levels were inversely associated with CACS (CAC+; odds ratio [OR] = 0.93, 95% confidence interval [CI] = 0.90–0.97) with similar inverse associations observed for Gensini and soft plaque scores. In contrast, monounsaturated (CAC + OR = 1.09, 95% CI = 1.03–1.15) and saturated fatty acids (CAC + OR = 1.08, 95% CI = 1.04–1.12) were positively associated with CAD burden. No consistent associations were observed with self-reported atrial fibrillation after multivariable adjustment. Plasma omega-6 fatty acids demonstrated inverse associations with imaging-defined CAD burden, suggesting a potential protective role that warrants investigation in longitudinal studies. Saturated and monounsaturated fatty acids were positively associated with CAD, aligning with prior evidence of their atherogenic potential.

Indexed as

Computed Tomography AngiographyCoronary Artery DiseaseFatty AcidsAgedBiomarkersCoronary AngiographyCross-Sectional StudiesFatty Acids, Omega-6FemaleHumansMaleMiddle AgedRisk FactorsBiomarkersFatty AcidsFatty Acids, Omega-6BiomarkerCardiovascular diseaseCoronary artery diseaseOmega-6Plasma fatty acids

Identifiers

PMID41593269
PMCPMC12905210

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.