ArticleCommunications chemistry2026
Direct diazotization of indoles with 2-Methoxyethyl nitrite.
Article in Communications chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
In pursuit of the reductive conversion of NO in organic synthesis, this study presents the direct diazotization of indoles using 2-methoxyethyl nitrite (MOE-ONO). Diazo compounds are invaluable intermediates in organic synthesis, serving as carbene precursors for constructing diverse carbon frameworks. However, traditional C-H diazotization methods often require azide compounds or excessive amounts of acid/base, posing significant environmental and safety challenges. Herein, we introduce a sustainable and efficient diazotization protocol that overcomes these problems. The use of 2-methoxyethyl nitrite (MOE-ONO), a stable and highly reactive NO donor developed by our group, in combination with TEMPO and a catalytic amount of Sc(OTf)
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