Evidence map›Paper›PMID 41593130›Full record

ArticleScientific reports2026

Development of a banana stem fiber-reinforced chitosan-xanthan gum wound healing patch loaded with Tridax procumbens extract for biomedical applications.

Umapathi Krishnamoorthy, HariSriram J K, Md Irfanul Haque Siddiqui, Yong Xu, Choon Kit Chan, Saurav Dixit, Subhav Singh, Sonawane R Chandrakant

Abstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Umapathi KrishnamoorthyDepartment of Biomedical Engineering, KIT-Kalaignarkarunanidhi Institute of Technology, Coimbatore, Tamil Nadu, India. umapathi.uit@gmail.com.
HariSriram J KDepartment of Biomedical Engineering, KIT-Kalaignarkarunanidhi Institute of Technology, Coimbatore, Tamil Nadu, India.
Md Irfanul Haque SiddiquiDepartment of Mechanical Engineering, College of Engineering, King Saud University, Riyadh, 12372, Saudi Arabia.
Yong XuGuangxi Key Laboratory of Sericulture Ecology and Intelligent Technology Application, Guangxi Collaborative Innovation Center of Modern Sericulture and Silk, School of Artificial Intelligence and Smart Manufacturing, Hechi University, Yizhou, China. xuyong@hcnu.edu.cn.
Choon Kit ChanFaculty of Engineering and Quantity Surveying, INTI International University, 71800, Nilai, Negeri Sembilan, Malaysia.
Saurav DixitCentre of Research Impact and Outcome, Chitkara University, Rajpura, 140417, Punjab, India.
Subhav SinghDivision of research and development, Lovely Professional University, Phagwara, Punjab, India.
Sonawane R ChandrakantSymbiosis Institute of Technology Pune, Symbiosis International Deemed University (SIU), Pune, 412115, India. Chandrakant.sonawane@sitpune.edu.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wound dressings, both in woven and non-woven forms, play a prominent role in wound healing. Traditionally, wound dressings are used for shielding wounds and absorbing exudates thus, protecting wound from infection. Recently, nature derived biopolymer wound dressings are emerging as potential materials that promote wound healing, in addition to protecting wounds. These polymeric wound dressing pose numerous limitations like lack of strength, inability to absorb excess exudate and difficulty in loading drugs when used individually in their native form. However, integrating different polymers to form Interpenetrating Polymeric Networks (IPNs) enable harvesting synergistic benefits. This paper presents one such novel bio-composite wound healing patch developed from hydrogel integration with banana pseudo stem fiber, chitosan and xanthan gum. The patch is loaded with natural extract from Tridax procumbens which is a known traditional wound healing drug. The developed IPN patch is characterized for physicochemical properties and its biological activities are validated. SEM results reveal that the bio-composite patch has slightly rough morphology with uniformly dispersed fiber in biopolymer matrix, XRD results demonstrated a crystallinity index of ~ 78.43%, and integration of various bio-active ingredients is validated from FTIR results. The wound healing bio-composite patch exhibited 60% antioxidant activity with an IC50 value of ~ 7.67 µg/ml. Further, scratch assay on L929 fibroblast cells revealed that the patch could achieve 78% wound closure in 24 h with 25 µg/ml concentration of drug and MTT assay on L929 fibroblast cells results confirmed cell viability of 75% with a concentration of 5 µg/ml of extract. These results demonstrate that the developed bio-composite patch could emerge as a potential wound healing material.

Indexed as

BandagesChitosanMusaPlant ExtractsPolysaccharides, BacterialWound HealingAnimalsAntioxidantsCell LineFibroblastsMicePlant StemsAntioxidantsChitosanPlant ExtractsPolysaccharides, Bacterialxanthan gumAntioxidantBanana fiberBio-compositeBiopolymerInterpenetrating polymeric networksProcess innovationT. procumbensWound dressingWound healing

Identifiers

PMID41593130
PMCPMC12905193

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.